Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

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Brief Title

Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

Official Title

Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

Brief Summary

      This study investigates the psychophysiological correlations of aggression and response to
      aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder
      (CD) and/or attention-deficit/hyperactivity disorder (ADHD). Data was gathered about
      participants' level of aggression through the Reactive-Proactive Aggression Questionnaire
      (RPQ). The stimuli that were presented to the participants included 1) a loud sound, 2)
      threatening photographs from the International Affective Picture System (IAPS), and 3) the
      Trier Social Stress Task (TSST). Participants' psychophysiological features of heart rate and
      galvanic skin conductance were measured and analyzed in relation to their RPQ scores and
      clinical diagnosis.
    



Study Type

Observational [Patient Registry]


Primary Outcome

Heart Rate


Condition

Conduct Disorder

Intervention

No intervention was administered for the purpose of this study.


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

133

Start Date

August 2011

Completion Date

August 2015

Primary Completion Date

August 2015

Eligibility Criteria

        Inclusion Criteria:

          1. Subjects between ages 7 and 16 years

          2. Subjects who fulfil all criteria for a DSM-IV diagnosis of ADHD, conduct disorder, or
             oppositional defiant disorder

          3. Subjects with willingness to participate in a randomized, double-blind controlled
             trial

          4. Subjects with complete written, informed parental consent and child assent

          5. Subjects with IQ of 70 or more

        Exclusion Criteria:

          1. Subjects who have IQ in the below 70

          2. Subjects who are younger than 7 years old or older than 16 years old

          3. Those without written parental consent

          4. Those with brain pathology such as serious head injury, epilepsy, etc.
      

Gender

All

Ages

7 Years - 16 Years

Accepts Healthy Volunteers

No

Contacts

Daniel Fung, , 



Administrative Informations


NCT ID

NCT03725371

Organization ID

YNC-SASSI-Quanti-1


Responsible Party

Principal Investigator

Study Sponsor

Yale-NUS College


Study Sponsor

Daniel Fung, Study Director, Institute of Mental Health, Singapore


Verification Date

October 2018