Brief Title
Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)
Official Title
Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure
Brief Summary
Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart
failure (CHF). Recent studies suggested that peripheral impairment was the major cause of
clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular
smooth muscle dysfunction. It results in increased peripheral resistance that may influence
limb blood flow, muscle fitness and activities of daily.The purposes of this study are
1. to compare muscular strength, endurance, and perfusion of quadriceps between CHF
patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS)
and difference in activities of daily living
2. to compare endothelium function between CHF patients and healthy control subjects
3. the relationship between endothelium function, muscular strength, endurance, perfusion,
and metabolism of quadriceps.
Study Type
Observational
Primary Outcome
muscle strength and endurance
Secondary Outcome
skeletal muscle oxygenation response
Condition
Chronic Heart Failure
Study Arms / Comparison Groups
Cardiovascular disease
Description: Diagnosis of cardiomyopathy or ischemic heart disease without heart failure
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
100
Start Date
May 2010
Completion Date
May 2011
Primary Completion Date
May 2011
Eligibility Criteria
Inclusion Criteria:
- Age 40-75 years
- Chronic heart failure: ejection fraction<40% and at stable condition
- Coronary Disease and dilated cardiomyopathy without heart failure
- Control group without diagnosis of any heart disease
Exclusion Criteria:
- Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases
that may affect the testing of the study
Gender
Male
Ages
40 Years - 75 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Ying-Tai Wu, Ph.D, +886-2-33668129, [email protected]
Location Countries
Taiwan
Location Countries
Taiwan
Administrative Informations
NCT ID
NCT01139086
Organization ID
201003050R
Study Sponsor
National Taiwan University Hospital
Study Sponsor
Ying-Tai Wu, Ph.D, Principal Investigator, National Taiwan University Hospital
Verification Date
June 2010