Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

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Brief Title

Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

Official Title

Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure

Brief Summary

      Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart
      failure (CHF). Recent studies suggested that peripheral impairment was the major cause of
      clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular
      smooth muscle dysfunction. It results in increased peripheral resistance that may influence
      limb blood flow, muscle fitness and activities of daily.The purposes of this study are

        1. to compare muscular strength, endurance, and perfusion of quadriceps between CHF
           patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS)
           and difference in activities of daily living

        2. to compare endothelium function between CHF patients and healthy control subjects

        3. the relationship between endothelium function, muscular strength, endurance, perfusion,
           and metabolism of quadriceps.
    



Study Type

Observational


Primary Outcome

muscle strength and endurance

Secondary Outcome

 skeletal muscle oxygenation response

Condition

Chronic Heart Failure


Study Arms / Comparison Groups

 Cardiovascular disease
Description:  Diagnosis of cardiomyopathy or ischemic heart disease without heart failure

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

100

Start Date

May 2010

Completion Date

May 2011

Primary Completion Date

May 2011

Eligibility Criteria

        Inclusion Criteria:

          -  Age 40-75 years

          -  Chronic heart failure: ejection fraction<40% and at stable condition

          -  Coronary Disease and dilated cardiomyopathy without heart failure

          -  Control group without diagnosis of any heart disease

        Exclusion Criteria:

          -  Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases
             that may affect the testing of the study
      

Gender

Male

Ages

40 Years - 75 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Ying-Tai Wu, Ph.D, +886-2-33668129, [email protected]

Location Countries

Taiwan

Location Countries

Taiwan

Administrative Informations


NCT ID

NCT01139086

Organization ID

201003050R



Study Sponsor

National Taiwan University Hospital


Study Sponsor

Ying-Tai Wu, Ph.D, Principal Investigator, National Taiwan University Hospital


Verification Date

June 2010