Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis

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Dilated cardiomyopathy
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Brief Title

Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis

Official Title

Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis.

Brief Summary

      The purpose of this study is evaluation of expression of desmin in cardiomyocytes of patients
      with idiopathic dilated cardiomyopathy. Analysis of relationship between desmin expression
      and activities of mitochondrium and expression of ubiquitin.

Study Type

Interventional

Primary Outcome

all cause mortality

Secondary Outcome

 qualitative differences in desmin expression in cardiomyocytes of patient with heart failure

Condition

Dilated Cardiomyopathy

Intervention

cardiobiopsy

Study Arms / Comparison Groups

 1
Description:  patients without heart failure, with cardiobiopsy

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Procedure

Estimated Enrollment

60

Start Date

January 2009

Completion Date

June 2011

Primary Completion Date

January 2011

Eligibility Criteria

        Inclusion Criteria:

          -  idiopatic dilated cardiomyopathy, NYHA I, II, III, IV

          -  dilated left ventricle

          -  ejection fraction below 45%

        Exclusion Criteria:

          -  diabetes mellitus

          -  kidney failure (GFR < 30, creatinine below 2,5 mg/dl

Gender

All

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

No

Contacts

, +48502133158, [email protected]

Location Countries

Poland

Location Countries

Poland

Administrative Informations

NCT ID

NCT00819442

Organization ID

N N402196135

Study Sponsor

Ministry of Scientific Research and Information Technology, Poland

Collaborators

 Polish Academy of Sciences

Study Sponsor

, ,

Verification Date

January 2009