Combination of Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy

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Brief Title

Combination of Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy

Official Title

Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy

Brief Summary

      The study proceeds with prospective, randomized, open and controlled clinical trials. The
      subject of the investigator's study was the first patient diagnosed with dilated
      cardiomyopathy. Subjects who agreed to participate in the study and were determined to meet
      the selection / exclusion criteria were randomly assigned to each group, and the experimental
      group was treated with 20 mg of olmesartan and 5 mg of rosuvastatin for 6 months, and the
      control group is treated with 40 mg of valsartan and 5 mg of rosuvastatin.
    

Detailed Description

      Myocardial viability plays an important role in improving the function of the heart. To date,
      the most reproducible and objective method has been established as a method or tool for
      assessing myocardial viability.

      Olmesartan is known to have the strongest inhibitory ability of angiotensin receptors
      compared with other angiotensin receptor binding inhibitors. Research has been reported that
      statin drugs may help improve vascular endothelial function, and several researchers have
      suggested that these mechanisms may affect the improvement of myocardial survival. In
      addition, studies have shown that angiotensin receptor binding inhibitors and statins may
      improve left ventricular function in patients with left ventricular function. However, since
      the studies did not assess myocardial survival, the mechanisms could not be clearly
      identified.

      The purpose of this study is to investigate the effect of olmesartan on myocardial survival
      in patients with dilated cardiomyopathy who have left ventricular dysfunction.
    

Study Phase

Phase 4

Study Type

Interventional


Primary Outcome

Rate of glucose metabolism


Condition

Dilated Cardiomyopathy

Intervention

Olmesartan 20 Mg Oral Tablet

Study Arms / Comparison Groups

 Study group
Description:  olmesartan 20mg with rosuvastatin 5mg once a day for 6-month

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

40

Start Date

September 1, 2019

Completion Date

December 31, 2020

Primary Completion Date

November 1, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  dilated cardiomyopathy

        Exclusion Criteria:

          -  contraindication to angiotensin receptor blocker

          -  cardiogenic shock

          -  sensitive to rosuvastatin

          -  liver cirrhosis more than Child class B
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Kyungil PARK, , 

Location Countries

Korea, Republic of

Location Countries

Korea, Republic of

Administrative Informations


NCT ID

NCT04174456

Organization ID

18-215


Responsible Party

Principal Investigator

Study Sponsor

Dong-A University


Study Sponsor

Kyungil PARK, Study Director, Dong-A University Hospital


Verification Date

November 2019