Brief Title
Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants
Official Title
Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants
Brief Summary
Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the present study, we intend to identify new related variants or genes. From March, 2003 to November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole exome sequencing was used to find out the variants associated with the onset of cardiomyopathy and its prognosis.
Study Type
Observational
Primary Outcome
Cardiovascular death confirmed by death comfirmation or interview with the relatives
Secondary Outcome
All cause death confirmed by death comfirmation or interview with the relatives
Condition
Dilated Cardiomyopathy
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
4000
Start Date
March 3, 2003
Completion Date
October 31, 2020
Primary Completion Date
October 31, 2020
Eligibility Criteria
Inclusion Criteria: · Patients diagnosed as cardiomyopathy according to the definition of American Heart Association Exclusion Criteria: - Uncontrolled hypertension significant valvular disease - Mild ischemic heart disease - Significant systemic infection - Thyroid-induced cardiomyopathy - Excessive alcohol consumption - Precious cancer treatment including irradiation - Refusal to participate in the study
Gender
All
Ages
N/A - N/A
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Dao Wen Wang, Doctor, 86-27-83663280, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT03754101
Organization ID
TJ-DM-GENE
Responsible Party
Principal Investigator
Study Sponsor
Tongji Hospital
Study Sponsor
Dao Wen Wang, Doctor, Study Chair, Tongji Hospital,Wuhan, Hubei, China, 430030
Verification Date
March 2020