Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants

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Brief Title

Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants

Official Title

Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants

Brief Summary

      Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the
      present study, we intend to identify new related variants or genes. From March, 2003 to
      November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their
      sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole
      exome sequencing was used to find out the variants associated with the onset of
      cardiomyopathy and its prognosis.
    



Study Type

Observational


Primary Outcome

Cardiovascular death confirmed by death comfirmation or interview with the relatives

Secondary Outcome

 All cause death confirmed by death comfirmation or interview with the relatives

Condition

Dilated Cardiomyopathy



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

4000

Start Date

March 3, 2003

Completion Date

October 31, 2020

Primary Completion Date

October 31, 2020

Eligibility Criteria

        Inclusion Criteria:

        · Patients diagnosed as cardiomyopathy according to the definition of American Heart
        Association

        Exclusion Criteria:

          -  Uncontrolled hypertension significant valvular disease

          -  Mild ischemic heart disease

          -  Significant systemic infection

          -  Thyroid-induced cardiomyopathy

          -  Excessive alcohol consumption

          -  Precious cancer treatment including irradiation

          -  Refusal to participate in the study
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Dao Wen Wang, Doctor, 86-27-83663280, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT03754101

Organization ID

TJ-DM-GENE


Responsible Party

Principal Investigator

Study Sponsor

Tongji Hospital


Study Sponsor

Dao Wen Wang, Doctor, Study Chair, Tongji Hospital,Wuhan, Hubei, China, 430030


Verification Date

March 2020