Brief Title
Brain Function and Perfusion in Patients With Heart Failure
Official Title
Brain Function and Perfusion in Patients With Heart Failure
Brief Summary
The investigators will evaluate the determinants of cerebral impairment in patients with
non-ischemic heart failure compared to controls, and its relation to cognitive function. They
hypothesize that patients with heart failure have impaired brain perfusion and hemodynamic
factors are associated with cognitive dysfunction.
Study Type
Observational
Primary Outcome
Determinants of cerebral impairment
Secondary Outcome
Prevalence of cognitive impairment
Condition
Heart Failure
Study Arms / Comparison Groups
Controls
Description: Age matched healthy subjects
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
45
Start Date
January 2012
Primary Completion Date
December 2012
Eligibility Criteria
Inclusion Criteria Control Group:
- Healthy subject, as assessed by clinician
- Age matched with patient group
Exclusion Criteria Control Group:
- Age < 18 years
- Carotid artery or intracranial disease, as assessed by echo-doppler (significant
stenosis > 50%)
- Unable or unwilling to undergo MRI
- The presence of ferromagnetic material in or on the body, for example tattoos with
ferrous ink or pacemakers or cardiac defibrillators. Also the presence of pregnancy
and claustrophobia.
- History of cognitive impairment
- Unable to understand procedures
- Unable or unwilling to provide informed consent
Inclusion Criteria DCM-group:
- Heart failure due to DCM
- 15 patients with NYHA class II
- 15 patients with NYHA class III/IV
Exclusion Criteria DCM-Group:
- Age < 18 years
- History of myocardial infarction
- History of peripheral artery disease
- History of cerebrovascular disease or
- Carotid artery or intracranial disease, as assessed by echo-doppler (significant
stenosis > 50%)
- History of cognitive impairment
- Unable to undergo MRI (eg pacemaker)
- Unable to understand procedures
- Unable or unwilling to provide informed consent
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
, +31 50 3612355, [email protected]
Location Countries
Netherlands
Location Countries
Netherlands
Administrative Informations
NCT ID
NCT01756014
Organization ID
BRAIN-HF
Responsible Party
Principal Investigator
Study Sponsor
University Medical Center Groningen
Study Sponsor
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Verification Date
December 2012