A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease

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Brief Title

A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease

Official Title

A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease

Brief Summary

      This study aims to identify and assess new CMR techniques that can improve current CMR
      protocols.
    

Detailed Description

      The aim of this study is to develop a comprehensive 10-minute protocol based on function and
      myocardial tissue characterization without the need for contrast injection, which can be
      standardized for 70% of cardiac patients.

      To test this 10-minute CMR protocol for its ability to significantly improve diagnostic
      decision-making and to reduce cost.

      To test its clinical feasibility, performance and cost-effectiveness in different populations
      including: Non-ischemic cardiomyopathies (-)OS-CMR and Ischemic Heart Disease and CAD
      (+)OS-CMR
    


Study Type

Observational


Primary Outcome

Primary diagnosis comparison between SMART CMR and standard CMR

Secondary Outcome

 SMART CMR scan completion percentage

Condition

Coronary Artery Disease


Study Arms / Comparison Groups

 Healthy Volunteers
Description:  Age: >18 y, No known current or pre-existing medical conditions that would affect the cardiovascular or respiratory system.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

2130

Start Date

December 12, 2019

Completion Date

January 31, 2025

Primary Completion Date

November 30, 2024

Eligibility Criteria

        Healthy Volunteers

        Inclusion Criteria:

          -  Age: > 18y, Informed consent No known current or pre-existing significant medical
             conditions that would affect the cardiovascular or respiratory system

        Exclusion Criteria:

          -  General MRI contraindications: MR- incompatible devices such as pacemakers,
             defibrillators, or implanted material or foreign bodies. Consumption of caffeinated
             drinks or foods (including cocoa and chocolate) during the 12 hours prior to the
             exam.Regular nicotine consumption during the last 6 months

        Patients

        Inclusion Criteria:

          -  Age: >18 y, Informed consent, Clinically indicated CMR exam

        Exclusion Criteria:

          -  General MRI contraindications: MR- incompatible devices such as pacemakers,
             defibrillators, or implanted material or foreign bodies Vasoactive medication (e.g.
             nitro) during the 12 hours prior to the exam. Consumption of caffeinated drinks or
             foods (including cocoa and chocolate) during the 12 hours prior to the exam.

        Regular nicotine consumption during the last 6 months
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Matthias G Friedrich, MD, 514-934-1934, [email protected]

Location Countries

Canada

Location Countries

Canada

Administrative Informations


NCT ID

NCT04464655

Organization ID

2020-6128


Responsible Party

Principal Investigator

Study Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre


Study Sponsor

Matthias G Friedrich, MD, Principal Investigator, Research Institute of the McGill University Health Center


Verification Date

July 2020