Quality of Life After Hysterectomy (AdenoQOL)

Learn more about:
Related Clinical Trial
The Use of Shear Wave Elastography, Transvaginal Ultrasound and Pelvic MRI in the Diagnosis of Adenomyosis Long-term Use of Mifepristone in the Treatment of Adenomyosis Radiofrequency Ablation of Adenomyosis Determination of the Incidence of Endometriosis and or Adenomyosis in Patients Diagnosed With Polycystic Ovary Syndrome, or the Incidence of Polycystic Ovary Syndrome in Patients Diagnosed With Endometriosis and or Adenomyosis The Effect of Adenomoyosis on Pregnancy Outcomes Observational Study of Patients Suffering From Endometriosis and Adenomyosis Factors Associated With Adenomyosis and a Clinical Scoring System for the Diagnosis Quality of Life After Hysterectomy (AdenoQOL) Low Molecular Weight Heparin on the Adenomyosis Patients’IVF-ET Outcome Diagnosis of Adenomyosis Using Ultrasound, Elastography and MRI Clinical and Molecular Study of Endometriosis and Adenomyosis Surgical Success After Laparoscopic vs Abdominal Hysterectomy Electronic Catheter Stethoscope Ovarian Reserve Modification After Lps Hysterectomy With Bilateral Salpingectomy Does 3D Laparoscopy Improve Vaginal Cuff Suture Time? Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Uterine Artery Embolization for Symptomatic Fibroids Oxytocin in MRI-HIFU To Compare to 2-channel and Multiple-channel Single Port Laparoscopic-assisted Vaginal Hysterectomy Effect of Addition of Steroids on Duration of Analgesia Paracervical Block in Laparoscopic Hysterectomy Use of Dexamethasone in Uterine Artery Embolization Treatment of Benign Uterine Disorders Using High Intensity Focused Ultrasound (MR-HIFU) Comparison of Estrogen-progestin Therapy in Continuous Regimen Versus Combination Estrogen-progestin Therapy in Continuous Regimen Plus Levonorgestrel-releasing Intrauterine System (LNG-IUS) Dienogest for Treatment of Adenomyotic Uteri Health-Related QoL Among Women Receiving Hysterectomy in NTUH Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis Adenomyosis and Ulipristal Acetate Efficacy of Acupuncture on Chronic Pelvic Pain in Women With Endometriosis or Adenomyosis LNG-IUS for Treatment of Dysmenorrhea Benefit of GnRH Agonist Before Frozen Embryo Transfer in Patients With Endometriosis and/or Adenomyosis Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis Adenomyosis: Genomic Mechanisms and Biological Response What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography Comparing Efficacy of Microwave vs Embolization Treatment for Adenomyosis Role of Dienogest in the Treatment of Patient With Symptomatic Adenomyosis Comparison of the Operation and Medical Treatment of Endometriosis and Adenomyosis A Prospective Study of Diagnostic Accuracy of Ultrasound Placebo-controlled Proof of Concept Study of Epelsiban in Women With Adenomyosis A Multi-omics Study of Adenomyosis Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis Levonorgestrel Intrauterine System and Adenomyosis Validation of the Adenomyosis Calculator Levonorgestrel-releasing Intrauterine System Versus a Low-dose Combined Oral Contraceptive for Management of Adenomyosis Uteri Modified Downregulation for Women With Adenomyosis of the Uterus Prior to Frozen-thawed Embryo Transfer. New Inflammation Markers for Distinguishing Uterine Adenomyosis and Leiomyoma The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms High-intensity Focused Ultrasound in Treatment of Uterine Adenomyosis Evaluation of Therapeutic Effect and Safety of Mifepristone in the Treatment of Adenomyosis Norwegian Adenomyosis Study III: Peristalsis Histopathological Diagnosis of Adenomyosis Norwegian Adenomyosis Study I Vaginal Bromocriptine for Treatment of Adenomyosis Levonorgestrel-releasing Intrauterine System for the Treatment of Symptomatic Adenomyosis

Brief Title

Quality of Life After Hysterectomy (AdenoQOL)

Official Title

Quality of Life After Hysterectomy for Adenomyosis and Other Benign Gynecological Conditions

Brief Summary

      Adenomyosis is a disease where ectopic endometrial-like glands affect the muscular wall of
      the uterus. About 70% of women affected by adenomyosis suffer from dysmenorrhea and
      menorrhagia. A levonorgestrel-releasing intrauterine device (LNG-IUD) is the first-choice
      treatment of adenomyosis, but is not always sufficiently effective in all women. Those women
      often end up removing the uterus (hysterectomy).

      Hysterectomy is clinically regarded to be an efficient and final treatment of adenomyosis,
      but pelvic pain may also prevail after removal of the uterus. This study aimes to investigate
      the short - and long-term impact of hysterectomy on quality of life (QOL) and sexual function
      in women with adenomyosis, and further to evaluate if there is any difference compared to
      women that are removing their uterus due to other benign gynecological conditions.

Study Type


Primary Outcome

The impact of hysterectomy on health related quality of life assessed by SF-36 sub scale bodily pain

Secondary Outcome

 The impact of hysterectomy on health related quality of life assessed by SF-36 sub scales





Study Arms / Comparison Groups

Description:  Patients with adenomyosis


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

March 18, 2021

Completion Date

December 2030

Primary Completion Date

October 30, 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Premenopausal status defined by having had menstruation within the last 12 months, or
             age < 50 years if amenorrhea due to hormonal treatment

          -  Hysterectomy planned due to a benign condition

          -  Able to communicate in Norwegian or English

          -  Electronic consent given

        Exclusion Criteria:

          -  Age < 18 years, postmenopausal status or no menstrual bleeding for the last 12 months

          -  Hysterectomy as part of female-to-male transition

          -  Pelvic organ prolapse as an indication for hysterectomy

          -  Gynecological cancer suspected at the time of inclusion

          -  Not able to communicate in Norwegian or English




18 Years - 52 Years

Accepts Healthy Volunteers



Marianne Omtvedt, MD, 004792441473, [email protected]

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

Oslo University Hospital

Study Sponsor

Marianne Omtvedt, MD, Principal Investigator, Oslo University Hospital

Verification Date

April 2022