Effect of Addition of Steroids on Duration of Analgesia

Learn more about:
Related Clinical Trial
Long-term Use of Mifepristone in the Treatment of Adenomyosis Radiofrequency Ablation of Adenomyosis Determination of the Incidence of Endometriosis and or Adenomyosis in Patients Diagnosed With Polycystic Ovary Syndrome, or the Incidence of Polycystic Ovary Syndrome in Patients Diagnosed With Endometriosis and or Adenomyosis The Effect of Adenomoyosis on Pregnancy Outcomes Observational Study of Patients Suffering From Endometriosis and Adenomyosis Factors Associated With Adenomyosis and a Clinical Scoring System for the Diagnosis Quality of Life After Hysterectomy (AdenoQOL) Low Molecular Weight Heparin on the Adenomyosis Patients’IVF-ET Outcome Diagnosis of Adenomyosis Using Ultrasound, Elastography and MRI Clinical and Molecular Study of Endometriosis and Adenomyosis Surgical Success After Laparoscopic vs Abdominal Hysterectomy Electronic Catheter Stethoscope Ovarian Reserve Modification After Lps Hysterectomy With Bilateral Salpingectomy Does 3D Laparoscopy Improve Vaginal Cuff Suture Time? Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Uterine Artery Embolization for Symptomatic Fibroids Oxytocin in MRI-HIFU To Compare to 2-channel and Multiple-channel Single Port Laparoscopic-assisted Vaginal Hysterectomy Effect of Addition of Steroids on Duration of Analgesia Paracervical Block in Laparoscopic Hysterectomy Use of Dexamethasone in Uterine Artery Embolization Treatment of Benign Uterine Disorders Using High Intensity Focused Ultrasound (MR-HIFU) Comparison of Estrogen-progestin Therapy in Continuous Regimen Versus Combination Estrogen-progestin Therapy in Continuous Regimen Plus Levonorgestrel-releasing Intrauterine System (LNG-IUS) Dienogest for Treatment of Adenomyotic Uteri Health-Related QoL Among Women Receiving Hysterectomy in NTUH Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis Adenomyosis and Ulipristal Acetate Efficacy of Acupuncture on Chronic Pelvic Pain in Women With Endometriosis or Adenomyosis LNG-IUS for Treatment of Dysmenorrhea Benefit of GnRH Agonist Before Frozen Embryo Transfer in Patients With Endometriosis and/or Adenomyosis Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis Adenomyosis: Genomic Mechanisms and Biological Response What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography Comparing Efficacy of Microwave vs Embolization Treatment for Adenomyosis Role of Dienogest in the Treatment of Patient With Symptomatic Adenomyosis Comparison of the Operation and Medical Treatment of Endometriosis and Adenomyosis A Prospective Study of Diagnostic Accuracy of Ultrasound Placebo-controlled Proof of Concept Study of Epelsiban in Women With Adenomyosis A Multi-omics Study of Adenomyosis Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis Levonorgestrel Intrauterine System and Adenomyosis Validation of the Adenomyosis Calculator Levonorgestrel-releasing Intrauterine System Versus a Low-dose Combined Oral Contraceptive for Management of Adenomyosis Uteri Modified Downregulation for Women With Adenomyosis of the Uterus Prior to Frozen-thawed Embryo Transfer. New Inflammation Markers for Distinguishing Uterine Adenomyosis and Leiomyoma The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms High-intensity Focused Ultrasound in Treatment of Uterine Adenomyosis Evaluation of Therapeutic Effect and Safety of Mifepristone in the Treatment of Adenomyosis Norwegian Adenomyosis Study III: Peristalsis Histopathological Diagnosis of Adenomyosis Norwegian Adenomyosis Study I Vaginal Bromocriptine for Treatment of Adenomyosis Levonorgestrel-releasing Intrauterine System for the Treatment of Symptomatic Adenomyosis

Brief Title

Effect of Addition of Steroids on Duration of Analgesia

Official Title

Prospective Randomized Controlled Clinical Trial: Superior Hypogastric Nerve Block for Pain Control After Uterine Artery Embolization: Effect of Addition of Steroids on Duration of Analgesia

Brief Summary

      The purpose of the study is to investigate the differences in post-procedural pain scores and
      narcotic use among patients who receive a Superior Hypogastric Nerve Block (SHNB) with and
      without corticosteroid performed as part of the Uterine Artery Embolization (UAE) procedure.

Detailed Description

      Investigators will enroll a total of 28 women undergoing the UAE procedure with 14 subjects
      in each study arm. This investigation is a single blind randomized control trial
      investigating the post-procedural analgesic effect of adding a corticosteroid (Triamcinolone)
      as an adjuvant to a SHNB that contains bupivacaine for patients undergoing UAE, compared to
      patients undergoing nerve block for pain control following UAE with local anesthetic only.
      Before and after the procedure, patients will be asked to complete online surveys in order to
      record their pain score (measured on the Visual Analog Pain Scale), opioid and other pain
      medication use, and other symptoms, such as nausea.

Study Phase

Early Phase 1

Study Type


Primary Outcome

Change in Pain Intensity Measure (mm)


Uterine Fibroids



Study Arms / Comparison Groups

Description:  During the Uterine Artery Embolization (UAE) procedure, participants in this arm receive bupivacaine and contrast to enable visualization of the nerve block under fluoroscopy.


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

November 5, 2019

Completion Date

February 2025

Primary Completion Date

February 2024

Eligibility Criteria

        Inclusion Criteria:

          -  females

          -  aged between 30 and 60 years

          -  diagnosed with symptomatic uterine fibroids and/or adenomyosis and scheduled to
             undergo UAE procedure

        Exclusion Criteria:

          -  Contraindications to UAE

          -  SHNB is deemed unsafe for the patient

          -  Allergies to local anesthetic or steroid agent

          -  History of inflammatory bowel disease or ulcerative colitis

          -  Uncorrectable abnormal coagulation profile

          -  Diabetes mellitus




30 Years - 60 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers


Jessica K Stewart, MD, 310-794-9202, [email protected]

Location Countries

United States

Location Countries

United States

Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

University of California, Los Angeles

Study Sponsor

Jessica K Stewart, MD, Principal Investigator, University of California, Los Angeles

Verification Date

March 2022