A Multi-omics Study of Adenomyosis

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Brief Title

A Multi-omics Study of Adenomyosis

Official Title

A Multi-omics Study on the Tumorigenesis of Adenomyosis

Brief Summary

      This study aims to analyze the multi-omics results between eutopic endometrium, adenomyosis
      and endometriosis of patients diagnosed of adenomyosis with and without endometriosis. The
      multi-omics profiles include whole exome sequencing, analysis of transcriptomics and
      metabolomics. A comprehensive multi-omics will reveal the pathogenesis of adenomyosis.
    



Study Type

Observational


Primary Outcome

Frequencies of somatic driving mutations

Secondary Outcome

 Frequencies of alteration of RNA expression

Condition

Adenomyosis

Intervention

A multi-omics analysis

Study Arms / Comparison Groups

 Group of adenomyosis
Description:  Patients with adenomyosis with or without endometriosis

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Combination Product

Estimated Enrollment

200

Start Date

November 10, 2018

Completion Date

November 23, 2020

Primary Completion Date

November 23, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Confirmed adenomyosis and/or endometriosis

          -  Signed an approved informed consents

          -  Feasible for biopsy

        Exclusion Criteria:

          -  Not meeting all of the inclusion criteria
      

Gender

Female

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Lei Li, M.D., 13911988831, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT03742843

Organization ID

AM-OMICS


Responsible Party

Sponsor-Investigator

Study Sponsor

Lei Li


Study Sponsor

Lei Li, M.D., Principal Investigator, Peking Union Medical College Hospital


Verification Date

November 2018