Low Molecular Weight Heparin on the Adenomyosis Patients’IVF-ET Outcome

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Brief Title

Low Molecular Weight Heparin on the Adenomyosis Patients'IVF-ET Outcome

Official Title

To Study the Effect of Low Molecular Weight Heparin on the Adenomyosis Patients'Outcome of in Vitro Fertilization-embryo Transplantation

Brief Summary

      In assisted reproductive technology, adenomyosis patients are characterized by lower clinical
      pregnancy rate, lower implantation rate and higher abortion rate. The purpose of this study
      is to explore whether low molecular weight heparin can reduce the abortion rate of
      adenomyosis patients in frozen thawed embryo transfer cycles.
    



Study Type

Interventional


Primary Outcome

Early spontaneous abortion rate


Condition

Adenomyosis

Intervention

Low molecular weight heparin

Study Arms / Comparison Groups

 Control Group
Description:  Adenomyosis patients in control group have normal luteal progesterone support.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

70

Start Date

February 1, 2020

Completion Date

January 31, 2022

Primary Completion Date

January 31, 2022

Eligibility Criteria

        Inclusion Criteria:

          1. The basal serum level of FSH was less than 10 IU / L

          2. Diagnosed with adenomyosis by ultrasound

          3. The first frozen thawed embryo transfer cycle, by hormone replacement protocol

          4. Transfer at least one high quality frozen embryo;

          5. Patients agreed to use low molecular weight heparin after FET, and they were able to
             sign informed consent in person.

        Exclusion Criteria:

          1. With abnormal karyotype;

          2. Accompanied with other uterine diseases: intrauterine adhesion, intramural myoma,
             moderate to severe endometriosis, congenital uterine malformation, endometrial
             tuberculosis, thin endometrium < 8mm on the day of transformation, etc;

          3. PCOS, RIF patients;

          4. There are indications of conventional anticoagulation or antiplatelet therapy, such as
             antiphospholipid syndrome, autoimmune diseases, coagulation dysfunction, etc;

          5. There were contraindications to hormone replacement therapy and low molecular weight
             heparin;

          6. Participating in other clinical studies;

          7. Unable to follow-up
      

Gender

Female

Ages

20 Years - 38 Years

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT04741295

Organization ID

SZ-2021-ADE1


Responsible Party

Principal Investigator

Study Sponsor

Nanjing University


Study Sponsor

, , 


Verification Date

February 2021