Prospective Radiological Study of HRCT to Predict Pathological Noninvasiveness in NSCLC

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Adenocarcinoma of lung
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Boehringer Ingelheim – Adenocarcinoma of lung
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Brief Title

Prospective Radiological Study of HRCT to Predict Pathological Noninvasiveness in NSCLC

Official Title

Prospective Radiological Study of HRCT to Predict Pathological Noninvasiveness in NSCLC

Brief Summary

      This study aims to evaluate the correlation between radiological diagnosis based on HRCT and
      pathological invasiveness. All enrolled patients receive HRCT examination before surgery.
      Investigators observe the radiological features and the correlation with the postoperative
      pathological findings.

Detailed Description

      Radiological findings determines the decision-making about the extent of primary surgical
      resection in adenocarcinoma of lung. Previous study showed the diagnosis of AIS/MIA and IAD
      based on radiological findings is correlated to the pathological diagnose. The purpose of
      this analysis is to define the role of radiological diagnosis.

Study Type

Observational

Primary Outcome

Specificity and Sensitivity

Secondary Outcome

 rate of positive radiological invasiveness

Condition

Adenocarcinoma of Lung

Study Arms / Comparison Groups

 patients
Description:  Patients with lung cancer who are candidates for surgery.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

601

Start Date

November 18, 2019

Completion Date

November 2020

Primary Completion Date

September 2020

Eligibility Criteria

        Inclusion Criteria:

          -  pulmonary nodule diagnosed by thoracic CT

          -  karnofsky performance status ≥60

          -  No surgical contraindication

          -  Patients who sign the informed consent

          -  Pre-operation clinical stage :T1abcN0M0

        Exclusion Criteria:

          -  Central lung tumor diagnosed by CT

          -  Tracheal or bronchus deformity diagnosed by CT

          -  Tracheal or bronchus disease history

          -  Severe smoking history #smoking index ≥400/year

Gender

All

Ages

20 Years - 75 Years

Accepts Healthy Volunteers

No

Contacts

, 18817875755, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT04165759

Organization ID

PRSHRCT

Responsible Party

Principal Investigator

Study Sponsor

Fudan University

Study Sponsor

, ,

Verification Date

November 2019