An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors

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Adenocarcinoma of lung
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Boehringer Ingelheim – Adenocarcinoma of lung
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Brief Title

An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors

Official Title

An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors

Brief Summary

      Patients are asked to participate in this study if they have been diagnosed with a thoracic
      carcinoma which includes lung cancer and have a gene mutation (alteration in the body's
      genetic instructions) and after undergoing treatment the cancer has come back, progressed, or
      shown a partial response on standard treatment.

Detailed Description

      In order to improve the treatment outcome for thoracic carcinomas after they become resistant
      to targeted therapy, the investigator is using tumor biopsies at the time of recurrence for
      genomic analysis to identify novel somatic changes in critical genes and gene pathways that
      can potentially be targeted with therapy. The study team is also creating patient-derived
      xenografts to test drug efficacy and optimize personalized therapy for each patient.

Study Type

Observational

Primary Outcome

Identify the number of molecular changes in the recurrent tumor through molecular analysis with gene panels.

Secondary Outcome

 Recording turn-around-time

Condition

Adenocarcinoma of Lung

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

15

Start Date

October 2014

Completion Date

December 2019

Primary Completion Date

October 2018

Eligibility Criteria

        Inclusion Criteria:

          -  18 years or older

          -  Thoracic carcinoma tumors are positive for any targetable genetic alterations

          -  Have shown partial or no response, progression or recurrence while on or after gene
             targeted therapy by CT/PET scan

          -  Tumor is accessible for biopsy or surgery

          -  Expected life is 6 months or longer.

        Exclusion Criteria:

          -  < 18 years

          -  Not able to communicate in English

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Jin Jen, MD, PhD, ,

Location Countries

United States

Location Countries

United States

Administrative Informations

NCT ID

NCT02616211

Organization ID

14-002084

Responsible Party

Principal Investigator

Study Sponsor

Mayo Clinic

Collaborators

 National Foundation for Cancer Research

Study Sponsor

Jin Jen, MD, PhD, Principal Investigator, Mayo Clinic

Verification Date

October 2020