Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of GGO LUAD Via WMS

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Adenocarcinoma of lung
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Boehringer Ingelheim – Adenocarcinoma of lung
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Brief Title

Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of GGO LUAD Via WMS

Official Title

Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of Ground Glass Opacity Featured Lung Adenocarcinoma Via Whole-Mount Section

Brief Summary

      This study aims to evaluate the correlations between radiologic features and pathologic
      subtypes of ground glass opacity featured lung adenocarcinoma via whole-mount section.

Detailed Description

      The pathological lepidic growth pattern was believed to relate to the ground-glass component,
      whereas invasive adenocarcinoma patterns relate to the solid component. However, the solid
      components might be fibrosis rather tumor; and previous studies demonstrated the ground-glass
      components might be invasive lesions. Therefore, it is of considerable significance to
      establish the correlations between radiologic features and pathologic subtypes of ground
      glass opacity featured lung adenocarcinoma.

Study Type

Observational

Primary Outcome

Evaluation of correlations between radiologic features and pathologic subtypes

Secondary Outcome

 Specificity, Sensitivity, and Repeatability

Condition

Adenocarcinoma of Lung

Study Arms / Comparison Groups

 Patients
Description:  Patients with ground glass opacity featured lung adenocarcinoma who are candidates for surgery.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

100

Start Date

June 1, 2021

Completion Date

May 1, 2022

Primary Completion Date

March 1, 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Ground glass opacity featured lung nodule diagnosed by thin-section computed
             tomography(TSCT)

          -  Pre-operation clinical IA stage

          -  Pulmonary lobectomy or segmentectomy

          -  Provision of informed consent

        Exclusion Criteria:

          -  Postoperative diagnosis of non-adenocarcinoma or mucinous adenocarcinoma

          -  The surgical specimens fail to satisfy requirement of inflation and formalin fixation

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Haiquan Chen, M.D., +86-21 64175590, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT05252676

Organization ID

IRB2106237-23

Responsible Party

Principal Investigator

Study Sponsor

Fudan University

Study Sponsor

Haiquan Chen, M.D., Principal Investigator, Fudan University

Verification Date

February 2022