Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center

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Adenocarcinoma of lung
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Boehringer Ingelheim – Adenocarcinoma of lung
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Brief Title

Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center

Official Title

Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center

Brief Summary

      The recent discovery of oncogenic drivers has revolutionized the management of advanced lung
      cancer by development of tyrosine kinase inhibitors targeted therapies. Prevalence of daily
      tobacco use is evaluated at 31,3 % in Grand-Est region, the only French region with a
      statistically significative difference for smoking habits. This region shows a higher
      incidence (+ 13 %) and mortality for lung cancer in comparison to the average for other
      French regions. The objectives of our studie were to estimate the distribution of oncogenic
      drivers and analyse their prognostic impacts in the Nancy University Hospital Center
      metastatic lung adenocarcinoma's population.

Study Type

Observational

Primary Outcome

Overall survival

Secondary Outcome

 Distribution in percentage of metastasis sites according oncogenic drivers

Condition

Adenocarcinoma of Lung Stage IV

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

114

Start Date

January 2011

Completion Date

December 2019

Primary Completion Date

December 2019

Eligibility Criteria

        Inclusion Criteria:

          -  Lung adenocarcinoma

          -  Patients diagnosed at a metastatic stage

          -  Patient who benefited an oncogenic driver research on their histologic samples

          -  Medical follow-up entirely done in Nancy Central Hospital

        Exclusion Criteria:

          -  Patients with double histology

          -  Synchronous cancer

          -  Patients with surgical care

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Angelica Tiotiu, ,

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT04493827

Organization ID

2019PI224

Responsible Party

Sponsor

Study Sponsor

Central Hospital, Nancy, France

Study Sponsor

Angelica Tiotiu, Study Director, Nancy Central Hospital

Verification Date

June 2020