Brief Title
Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center
Official Title
Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center
Brief Summary
The recent discovery of oncogenic drivers has revolutionized the management of advanced lung cancer by development of tyrosine kinase inhibitors targeted therapies. Prevalence of daily tobacco use is evaluated at 31,3 % in Grand-Est region, the only French region with a statistically significative difference for smoking habits. This region shows a higher incidence (+ 13 %) and mortality for lung cancer in comparison to the average for other French regions. The objectives of our studie were to estimate the distribution of oncogenic drivers and analyse their prognostic impacts in the Nancy University Hospital Center metastatic lung adenocarcinoma's population.
Study Type
Observational
Primary Outcome
Overall survival
Secondary Outcome
Distribution in percentage of metastasis sites according oncogenic drivers
Condition
Adenocarcinoma of Lung Stage IV
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
114
Start Date
January 2011
Completion Date
December 2019
Primary Completion Date
December 2019
Eligibility Criteria
Inclusion Criteria: - Lung adenocarcinoma - Patients diagnosed at a metastatic stage - Patient who benefited an oncogenic driver research on their histologic samples - Medical follow-up entirely done in Nancy Central Hospital Exclusion Criteria: - Patients with double histology - Synchronous cancer - Patients with surgical care
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Angelica Tiotiu, ,
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT04493827
Organization ID
2019PI224
Responsible Party
Sponsor
Study Sponsor
Central Hospital, Nancy, France
Study Sponsor
Angelica Tiotiu, Study Director, Nancy Central Hospital
Verification Date
June 2020