Comparative Genomic Profiling of Lung Adenocarcinoma in Asians and Caucasians: A Propensity Matched Analysis

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Adenocarcinoma of lung
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Boehringer Ingelheim – Adenocarcinoma of lung
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Brief Title

Comparative Genomic Profiling of Lung Adenocarcinoma in Asians and Caucasians: A Propensity Matched Analysis

Official Title

Comparative Genomic Profiling of Lung Adenocarcinoma in Asians and Caucasians: A Propensity Matched Analysis

Brief Summary

      Lung adenocarcinomas (LUADs) from Asian ancestry are reported to have different genomic
      architectures compared with LUADs from Caucasian ancestry. However, due to lack of available
      cases, few studies controlled the clinical attributes during the comparisons of the genomic
      alterations. In this study, the investigators will identify Asian LUADs patients who had
      broad-panel next-generation sequencing (NGS) performed on their primary tumor between January
      2018 and December 2019 at the department of thoracic surgery of Peking University People's
      Hospital. Then, Caucasian LUADs patients who had targeted NGS (Memorial Sloan
      Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) will be
      identified in the GENIE database, which consists of 6673 primary lung adenocarcinoma samples
      with clinical annotations. Finally, genomic alterations regarding somatic mutations, copy
      number variations, fusions, mutational signatures, oncogenic pathways, and therapeutic
      actionability will be comprehensively compared between these two cohorts after adjusting age,
      sex, smoking status, and pathologic stage using propensity score matching. This study will
      elucidate important ancestry differences between Asian and Caucasian lung adenocarcinoma
      patients.

Study Type

Observational

Primary Outcome

Oncoprint of somatic mutations

Condition

Adenocarcinoma of Lung

Study Arms / Comparison Groups

 Asian lung adenocarcinoma
Description:  Asian LUADs patients who had broad-panel next-generation sequencing (NGS) performed on their primary tumor between January 2018 and December 2019 at the department of thoracic surgery of Peking University People's Hospital

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

450

Start Date

January 2021

Completion Date

December 2021

Primary Completion Date

July 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Primary lung adenocarcinoma

          -  Broad-panel next-generation sequencing

          -  Asian

        Exclusion Criteria:

          -  Inadequate clinicopathological information

          -  Low-quality next-generation sequencing

Gender

All

Ages

18 Years - 85 Years

Accepts Healthy Volunteers

No

Contacts

, 010-88326650, [email protected]

Administrative Informations

NCT ID

NCT04692935

Organization ID

2020PHB375

Responsible Party

Sponsor-Investigator

Study Sponsor

Jun Wang

Collaborators

 Berry Genomics Co., Ltd.

Study Sponsor

, ,

Verification Date

January 2021