Brief Title
Bortezomib in Treating Patients With Stage IIIB or Stage IV Lung Cancer
Official Title
Phase II Study of Bortezomib (PS-341) for Patients With Advanced Bronchiolo-Alveolar Carcinoma (BAC) or Adenocarcinoma With BAC Features
Brief Summary
This phase II trial is studying how well bortezomib works in treating patients with stage IIIB or stage IV lung cancer. Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Detailed Description
PRIMARY OBJECTIVES: I. Determine the objective response rate in patients with stage IIIB or IV bronchoalveolar carcinoma (BAC) or adencarcinoma of the lung with BAC features treated with bortezomib. SECONDARY OBJECTIVES: I. Determine the progression-free and overall survival of patients treated with this drug. II. Determine the time to disease progression in patients treated with this drug. III. Determine predictors of response, based on molecular correlative studies of tumor and blood, in patients with treated with this drug. OUTLINE: This is a multicenter study. Patients are stratified according to prior epidermal growth factor receptor inhibitor therapy (yes vs no). Patients receive bortezomib IV over 3-5 seconds on days 1 and 8. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed for survival.
Study Phase
Phase 2
Study Type
Interventional
Primary Outcome
Objective Response Rate With Bortezomib Evaluated by Both RECIST Criteria and Computer-assisted Image Analysis.
Secondary Outcome
Progression-free Survival
Condition
Adenocarcinoma of the Lung
Intervention
bortezomib
Study Arms / Comparison Groups
Arm I
Description: Patients receive bortezomib IV over 3-5 seconds on days 1 and 8.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
42
Start Date
June 2005
Completion Date
December 2010
Primary Completion Date
December 2010
Eligibility Criteria
Criteria: - Histologically confirmed bronchoalveolar carcinoma (BAC) or adenocarcinoma of the lung with BAC features: - Stage IIIB or IV disease: - Patients with stage IIIB disease must be ineligible for definitive combined modality treatment with radiotherapy and chemotherapy - Measurable disease, defined as >= 1 unidimensionally measurable lesion >= 20 mm by conventional techniques or >= 10 mm by spiral CT scan: - Previously irradiated lesions are considered measurable only if lesion progressed after completion of radiotherapy - No unstable brain metastases: - Brain metastases that are stable for ≥ 1 month after completion of prior radiotherapy, stereotactic surgery, or surgery are allowed - Performance status: - ECOG 0-2 - Life expectancy >3 months - Hepatic: - Bilirubin normal - AST and ALT =< 2.5 times upper limit of normal - Renal: - Creatinine normal OR creatinine clearance >= 60 mL/min - Cardiovascular: - No symptomatic congestive heart failure - No unstable angina pectoris - No cardiac arrhythmias - No more than 1 prior chemotherapy regimen for advanced BAC: - Prior gefitinib or other known epidermal growth factor receptor (EGFR) inhibitors are not considered a systemic chemotherapy regimen - At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) - At least 4 weeks since prior corticosteroids - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception before, during, and for 30 days after completion of study treatment - No ongoing or active infection - No other malignancy within the past 3 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated stage I or II cancer that is in complete remission - No peripheral neuropathy >= grade 2 - No known hypersensitivity to bortezomib, boron, or mannitol - No psychiatric illness or social situation that would preclude study compliance - No other uncontrolled illness - No concurrent routine granulocyte colony-stimulating factors (e.g., filgrastim [G-CSF] or sargramostim [GM-CSF]) - At least 2 weeks since prior radiotherapy - Recovered from prior therapy (alopecia allowed) - At least 2 weeks since prior EGFR inhibitors - At least 4 weeks since prior anticonvulsants - No prior bortezomib - No concurrent antiretroviral therapy for HIV-positive patients - No other concurrent investigational agents - No other concurrent anticancer therapy - Concurrent bisphosphonates for bone metastases allowed - Hematopoietic: - Absolute neutrophil count >= 1,500/mm3 - Platelet count >= 100,000/mm3
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
David Gandara, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00118144
Organization ID
NCI-2009-00113
Secondary IDs
NCI-2009-00113
Responsible Party
Sponsor
Study Sponsor
National Cancer Institute (NCI)
Study Sponsor
David Gandara, Principal Investigator, City of Hope Medical Center
Verification Date
April 2013