Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia

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Brief Title

Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia

Official Title

Effects of Valproic Acid and Magnesium Sulphate on Rocuronium Requirement and Postoperative Analgesia in Patients Undergoing Craniotomy for Cerebrovascular Surgery

Brief Summary

      The investigators hypothesized that valproic acid will increase rocuronium requirement and
      MgSO4 infusion would reduce requirement of muscle relaxant in craniotomy patients preloaded
      with sodium valproate.
    

Detailed Description

      Magnesium sulfate (MgSO4) is known to reduce requirement of muscle relaxant.
    


Study Type

Interventional


Primary Outcome

Rocuronium

Secondary Outcome

 hemodynamics

Condition

Cerebral Aneurysm

Intervention

Magnesium Sulfate

Study Arms / Comparison Groups

 Mg_orfil
Description:  patients preloaded with sodium valproate receives MgSO4 during the craniotomy.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

60

Start Date

October 2011

Completion Date

December 2011

Primary Completion Date

December 2011

Eligibility Criteria

        Inclusion Criteria:

          -  18- 65 years

          -  American society of anesthesiology physical status 1,2

          -  scheduled for elective craniotomy for aneurysm clipping or for superficial temporal
             artery-middle cerebral artery anastomosis

        Exclusion Criteria:

        body mass index <18.5 or >24.9 kg m-2; neuromuscular, renal, cardiovascular or hepatic
        insufficiency; Glasgow coma scale (GCS) <15; allergy to the study drugs; medications
        influencing NDMRs; breast feeding; pregnancy; and preoperative epilepsy.
      

Gender

All

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

No

Contacts

Sanghwan Do, Doctor, 82-31-787-7499, [email protected]

Location Countries

Korea, Republic of

Location Countries

Korea, Republic of

Administrative Informations


NCT ID

NCT01460563

Organization ID

Mg_orfil


Responsible Party

Principal Investigator

Study Sponsor

Seoul National University Bundang Hospital


Study Sponsor

Sanghwan Do, Doctor, Study Chair, Seoul National University Bundang Hospital


Verification Date

December 2011