Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery

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Brief Title

Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery

Official Title

Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery

Brief Summary

      Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce
      neural damage during neurosurgery.

      As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial
      NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is
      preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in
      clinical use. But there have been no reports about the effect of changing NMB agent on
      efficacy of MEP monitoring.

      Therefore, the investigators performed a randomized controlled trial to evaluate the effect
      of changing NMB agent on the variability of MEP amplitude during neurosurgery.
    

Detailed Description

      Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce
      neural damage during neurosurgery.

      As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial
      NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is
      preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in
      clinical use. But there have been no reports about the effect of changing NMB agent on
      efficacy of MEP monitoring.

      Therefore, the investigators performed a randomized controlled trial to evaluate the effect
      of changing NMB agent on the variability of MEP amplitude during neurosurgery.
    


Study Type

Interventional


Primary Outcome

MEP amplitude

Secondary Outcome

 Coefficient of variation (CV) of MEP amplitude

Condition

Motor Evoked Potential Monitoring

Intervention

MEP monitoring with continuous infusion of vecuronium during general anesthesia

Study Arms / Comparison Groups

 Cisatracurium Group
Description:  MEP monitoring with continuous infusion of cisatracurium during general anesthesia

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

74

Start Date

July 2012

Completion Date

March 2013

Primary Completion Date

March 2013

Eligibility Criteria

        Inclusion Criteria:

          -  Adult patients undergoing neurosurgery with intraoperative motor evoked potential
             monitoring

        Exclusion Criteria:

          -  Patients who can not undergo motor evoked potential monitoring due to central or
             peripheral neuromuscular disease (e.g. Cerebral palsy, Myasthenia gravis, Acute spinal
             injury, neurologic shock)

          -  Patients with hepatic or renal disease with altered metabolism of vecuronium

          -  Patients with medication which influence the metabolism of vecuronium (e.g. calcium
             channel blocker, aminoglycoside antibiotics, Lithium, MgSO4)
      

Gender

All

Ages

20 Years - 75 Years

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

Korea, Republic of

Location Countries

Korea, Republic of

Administrative Informations


NCT ID

NCT01690364

Organization ID

2012-05-090-001


Responsible Party

Principal Investigator

Study Sponsor

Samsung Medical Center


Study Sponsor

, , 


Verification Date

December 2013