Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage

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Brief Title

Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage

Official Title

Computed Tomographic Perfusion and Computed Tomographic Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage

Brief Summary

      Cerebral vasospasm is a devastating complication of subarachnoid hemorrhage after cerebral
      aneurysm rupture leading to cerebral ischemia and potentially cerebral infarction. The
      current gold standard diagnostic imaging study for cerebral vasospasm is catheter cerebral
      angiography, an invasive diagnostic procedure carrying a complication rate of 1-2% per
      procedure. Computed tomographic perfusion imaging (CTP) and computed tomographic angiography
      (CTA) are noninvasive diagnostic imaging studies frequently utilized in the evaluation of
      embolic and thrombotic cerebral infarct. The investigators hypothesize that CTP and CTA may
      be utilized as screening tools for cerebral vasospasm following aneurysmal subarachnoid
      hemorrhage requiring treatment and provide prognostic information.
    



Study Type

Observational


Primary Outcome

CT perfusion parameters

Secondary Outcome

 Disposition at discharge

Condition

Cerebral Vasospasm


Study Arms / Comparison Groups

 CTA/CTP
Description:  Patients undergo CTA/CTP imaging prior to cerebral angiography

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

4

Start Date

September 2009

Completion Date

December 2011

Primary Completion Date

December 2011

Eligibility Criteria

        Inclusion Criteria:

          -  subarachnoid hemorrhage after aneurysm rupture

        Exclusion Criteria:

          -  renal insufficiency

          -  pregnancy

          -  contrast reaction
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Michelle Miller-Thomas, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00962546

Organization ID

HRPO 09-0950


Responsible Party

Principal Investigator

Study Sponsor

Washington University School of Medicine


Study Sponsor

Michelle Miller-Thomas, MD, Principal Investigator, Washington University School of Medicine


Verification Date

December 2014