Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage

Learn more about:
Related Clinical Trial
Variability in Transcranial Doppler Technique in Neuro-Critical Care Patients Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery Safety and Clinical Effectiveness of Pipeline™ Shield Devices for Intracranial Aneurysms Intraoperative Fluorescence With Augmented Reality Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Amnesia After Surgery for Anterior Communicating Aneurysm: High Resolution Magnetic Resonance (MR) Imaging Findings Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage The RISE Trial: A Randomized Trial on Intra-Saccular Endobridge Devices Multicenter Retrospective Registry of Anterior Communicating Artery Aneurysms With Endovascular Therapy Esmolol Infusion in Patients Undergoing Craniotomy Surpass Flow Diverter for Intracranial Aneurysms: SURMOUNT Registry Data Collection Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia Optical Coherence Tomography Imaging of Post Coil Aneurysm Healing. Registry for Study of Coils in Intracranial Aneurysms EEG Monitoring to Assess Emergence From Neuroanesthesia DELTA Trial: Does Embolization With Larger Coils Lead to Better Treatment of Aneurysms Trial Hydrogel Endovascular Aneurysm Treatment Trial Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Remote Ischemic Preconditioning for Intracranial Aneurysm Treatment Doppler Flow Wires in Cerebral Angiography Safety Study of Minimally Invasive Approaches to Unruptured Anterior Circulation Aneurysms Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome New Findings About Somatosensory Evoked Potentials (SEP) During Surgery for Cerebral Aneurysms Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity Use of Classic LMA During Endovascular Therapy HydroCoil Cerebral Aneurysm Treatment Trial Ticagrelor vs Clopidogrel for Platelet Inhibition in Stenting for Cerebral Aneurysm Goal-directed Therapy in Endovascular Coiling of Cerebral Aneurysm Patients Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2 Decision Aids in Cerebral Aneurysm Treatment Framing Eighteen Coils in Cerebral Aneurysms Trial Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1

Brief Title

Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage

Official Title

Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage

Brief Summary

      Subarachnoid haemorrhage (SAH) may cause damage to the hypotalamo-pituitary-adrenal axis
      (HPA) thus disturbing the hormonal response of these structures.

      The aim of our study is to characterize the function of HPA-axis acutely and over time up to
      three months in patients with SAH.
    

Detailed Description

      The hypotalamo-pituitary-adrenal (HPA)-axis may be affected in SAH by temporary or permanent
      damage to the hypothalamus and/or pituitary gland. Also surgery or endovascular treatment of
      a ruptured intracranial aneurysm may affect the hormonal response of the HPA-axis. Some data
      suggest a high incidence of delayed endocrine abnormalities in patients with SAH but only
      little data exists on the acute endocrine abnormalities in this disease.

      We will study the pituitary-adrenal hormone levels in patients with acute aneurysmal SAH and
      patients admitted for elective cranial aneurysm surgery will serve as a control population.
      We will use serum free cortisol calculation and total cortisol measurements as well as
      adrenocorticotrophic hormone (ACTH) stimulation test in assessing the responsiveness of the
      adrenal gland to exogenous ACTH. The hormone levels will be measured repeatedly during the
      first seven days after SAH and once at three months.
    


Study Type

Observational




Condition

Subarachnoid Hemorrhage


Study Arms / Comparison Groups

 2
Description:  Patients scheduled for elective cerebral aneurysmal surgery

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

46

Start Date

March 2006

Completion Date

January 2008

Primary Completion Date

November 2006

Eligibility Criteria

        Inclusion Criteria:

        SAH-group:

          -  >age 18,

          -  Subarachnoid hemorrhage due to an cerebral aneurysm

        Control group:

          -  Age >18

          -  Admitted for elective primary cerebral aneurysm surgery

        Exclusion Criteria:

        SAH group:

          -  Any corticoid treatment (also inhaled)

          -  Usage of etomidate before study entry or during the study period

          -  Exact bleeding day unknown

          -  Previous history of SAH or more than three days of current bleeding

          -  Previous aneurysm surgery or embolization

          -  Traumatic SAH

          -  Known pituitary insufficiency and moribund state of the patient

          -  Refusement of the patient

        control group:

          -  Any corticoid treatment (also inhaled)

          -  Usage of etomidate before study entry or during the study period

          -  Previous history of SAH or cerebral aneurym surgery or embolization

          -  Admitted for elective aneurysm embolization

          -  Known pituitary insufficiency

          -  Refusement of the patienT
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Stepani J Bendel, MD, , 

Location Countries

Finland

Location Countries

Finland

Administrative Informations


NCT ID

NCT00614887

Organization ID

KUH5070184

Secondary IDs

5070184


Study Sponsor

Kuopio University Hospital

Collaborators

 University of Eastern Finland

Study Sponsor

Stepani J Bendel, MD, Principal Investigator, Department of Intensive Care, Kuopio University Hospital, FINLAND


Verification Date

January 2008