Doppler Flow Wires in Cerebral Angiography

Learn more about:
Related Clinical Trial
Variability in Transcranial Doppler Technique in Neuro-Critical Care Patients Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery Safety and Clinical Effectiveness of Pipeline™ Shield Devices for Intracranial Aneurysms Intraoperative Fluorescence With Augmented Reality Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Amnesia After Surgery for Anterior Communicating Aneurysm: High Resolution Magnetic Resonance (MR) Imaging Findings Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage The RISE Trial: A Randomized Trial on Intra-Saccular Endobridge Devices Multicenter Retrospective Registry of Anterior Communicating Artery Aneurysms With Endovascular Therapy Esmolol Infusion in Patients Undergoing Craniotomy Surpass Flow Diverter for Intracranial Aneurysms: SURMOUNT Registry Data Collection Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia Optical Coherence Tomography Imaging of Post Coil Aneurysm Healing. Registry for Study of Coils in Intracranial Aneurysms EEG Monitoring to Assess Emergence From Neuroanesthesia DELTA Trial: Does Embolization With Larger Coils Lead to Better Treatment of Aneurysms Trial Hydrogel Endovascular Aneurysm Treatment Trial Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Remote Ischemic Preconditioning for Intracranial Aneurysm Treatment Doppler Flow Wires in Cerebral Angiography Safety Study of Minimally Invasive Approaches to Unruptured Anterior Circulation Aneurysms Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome New Findings About Somatosensory Evoked Potentials (SEP) During Surgery for Cerebral Aneurysms Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity Use of Classic LMA During Endovascular Therapy HydroCoil Cerebral Aneurysm Treatment Trial Ticagrelor vs Clopidogrel for Platelet Inhibition in Stenting for Cerebral Aneurysm Goal-directed Therapy in Endovascular Coiling of Cerebral Aneurysm Patients Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2 Decision Aids in Cerebral Aneurysm Treatment Framing Eighteen Coils in Cerebral Aneurysms Trial Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1

Brief Title

Doppler Flow Wires in Cerebral Angiography

Official Title

Predicting Cerebral Aneurysm Recurrence Using Doppler Guidewire Measurements

Brief Summary

      The purpose of this study is to use a wire with a Doppler tip to measure blood flow in
      vessels in the brain and determine hemodynamic factors associated with treatment success or
      failure. Many neurological diseases cause abnormal blood flow in the brain in specific
      vessels. The special wire used in this study is place into brain blood vessels during
      standard of care procedure to treat such diseases, and blood flow parameters (such as
      velocity and pressure) are measured to gain better understanding of these neurological

Detailed Description

      Current treatments of cerebral aneurysms are imperfect, and aneurysmal hemodynamics is an
      important factor in treatment failure. The identification of hemodynamic factors that
      influence treatment success could predict outcome. Published studies show that the
      hemodynamic environment of aneurysms changes after treatment, and there is limited
      retrospective evidence that the degree of change affects treatment success. However, previous
      hemodynamic calculations did not have access to patient-specific measurements of blood flow,
      which substantially reduced their accuracy. In addition, no prospective studies of the
      predictive value of post-treatment aneurysm hemodynamics have been done.

      Methods: Prospectively test new aneurysm patients for hemodynamic predictors of treatment
      outcome based upon the hypothesis long-term aneurysm treatment outcome can be prospectively
      predicted by measuring the immediate hemodynamic effects of aneurysm treatment with novel
      patient-specific modeling techniques. Task 1: In a new cohort of patients undergoing aneurysm
      treatment, the investigators will again use Doppler guidewire measurements to create
      patient-specific hemodynamic models of treatment effects. By prospectively applying the
      knowledge of crucial hemodynamic changes the investigators will use immediate post-treatment
      hemodynamics to predict long-term treatment outcome.

Study Type


Primary Outcome

Treatment Prediction




* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment


Start Date

June 1, 2020

Completion Date

June 1, 2020

Primary Completion Date

June 1, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Patient with an unruptured intracranial aneurysm ≥ 5mm in size undergoes endovascular
             treatment and subsequent angiographic follow-up

        Exclusion Criteria:

        -previously enrolled in the study




18 Years - N/A

Accepts Healthy Volunteers



Louis J Kim, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

University of Washington

Study Sponsor

Louis J Kim, MD, Principal Investigator, University of Washington Department of Neurological Surgery

Verification Date

September 2020