Brief Title
Use of Human Papillomavirus Persistence for Determination of Treatment Efficacy Among Women With Cervical Dysplasia
Official Title
Evaluation of the Use of Human Papillomavirus Persistence for Determination of the Treatment Efficacy Among Women With Cervical Intraepithelial Neoplasia, and for Prediction of Recurrence of Cervical Disease
Brief Summary
The objectives are to evaluate the effectiveness of treatment of cervical intraepithelial neoplasia (CIN) by loop electrosurgical excision procedure using persistence of human papillomavirus (HPV) as outcome, and to perform a long-term follow-up on the ability of HPV testing, as compared to cytology, to predict recurrence of high-grade CIN.
Detailed Description
Cervical samples for human papillomavirus (HPV) DNA analysis and cytological analysis were obtained from women with abnormal smears referred to Umeå university hospital, Sweden, for treatment with conization. These women were scheduled for HPV DNA testing and Pap smears before and 3, 6, 12, 24 and 36 months after treatment. The HPV DNA testing was performed with a PCR-based genotyping method.
Study Type
Observational
Condition
Human Papillomavirus Infection
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
195
Start Date
February 2001
Completion Date
November 2005
Eligibility Criteria
Inclusion Criteria: - Referral to Umeå university hospital for treatment due to abnormal Pap smear. Exclusion Criteria: - Lack of informed consent.
Gender
Female
Ages
N/A - N/A
Accepts Healthy Volunteers
No
Contacts
Anna Söderlund Strand, PhD, ,
Location Countries
Sweden
Location Countries
Sweden
Administrative Informations
NCT ID
NCT00931190
Organization ID
95-240
Study Sponsor
Lund University
Collaborators
Swedish Cancer Society
Study Sponsor
Anna Söderlund Strand, PhD, Principal Investigator, Dept. medical microbiology, Malmö university hospital, Malmö, Sweden
Verification Date
September 2009