Brief Title
Cervical Cancer Screening Strategies
Official Title
A Retrospective Cohort Study on the Effectiveness of Various Screening Strategies for Uterine Cervical Cancer
Brief Summary
This study is to investigate retrospectively the results of cervical cytology and high-risk human papillomavirus in the past 20 years recorded in Peking Union Medical College Hospital. The histological findings after cervical cancer screening were reviewed. The diagnostic values of different screening strategies were compared based on the results of cervical histology. The primary endpoint is the diagnosis of grade 2 cervical intraepithelial neoplasia (CIN2) or more severe lesions (CIN2+). The secondary endpoints include following objectives: (1) the invasive procedures needed according to the screening results; (2) the diagnosis of vaginal and/or vulval intraepithelial neoplasia; (3) the persistence and recurrence of human papillomavirus infection; and (4) the cost-effectiveness of screening strategies for CIN2+.
Study Type
Observational
Primary Outcome
CIN2+
Secondary Outcome
Invasive procedures
Condition
Cervical Cancer
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
10000
Start Date
March 19, 2022
Completion Date
March 19, 2025
Primary Completion Date
March 19, 2024
Eligibility Criteria
Inclusion Criteria: - Aged 18 years or older - With definite cervical histology after cervical cancer screening, ore with at least one screening test after first testing Exclusion Criteria: - Not meeting all of the inclusion criteria
Gender
Female
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Lei Li, M.D., 86-139-1198-8831, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT05309122
Organization ID
EVUCC
Responsible Party
Sponsor-Investigator
Study Sponsor
Lei Li
Study Sponsor
Lei Li, M.D., Principal Investigator, Peking Union Medical College Hospital
Verification Date
March 2022