Stem Cells for Bronchopulmonary Dysplasia

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Bronchopulmonary dysplasia
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Brief Title

Stem Cells for Bronchopulmonary Dysplasia

Official Title

Stem Cells for Bronchopulmonary Dysplasia: a Cohort Study

Brief Summary

      Very preterm infants are at high risk to develop to bronchopulmonary dysplasia (BPD) for the
      lack of effective measures to prevent or ameliorate this common and serious disorder. BPD
      remains a major cause of mortality and lifelong morbidity in preterm infants

Detailed Description

      Several studies have shown that transplantation of mesenchymal stem cells (MSCs) in
      immunocompetent animals attenuates lung injury, such as impaired alveolarization,
      inflammatory response, increased apoptosis, and fibrosis. Human umbilical cord blood (hUCB)
      is considered a better source of MSCs because of their ready availability and greater
      proliferative capacity and less antigenicity than other cell types.

      transplantation of hUCB-derived MSCs should be effective in treating BPD. The safety and
      efficacy of MSC transplantation for prevention of BPD has not been tested previously,
      however.

Study Phase

Early Phase 1

Study Type

Interventional

Primary Outcome

death

Secondary Outcome

 Bayley Scales of Infant Development

Condition

Bronchopulmonary Dysplasia

Intervention

transplantation of mesenchymal stem cell

Study Arms / Comparison Groups

 transplantation of mesenchymal stem cell
Description:  transplantation of mesenchymal stem cell will be given to the infants with BPD.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

100

Start Date

November 1, 2017

Completion Date

December 30, 2022

Primary Completion Date

December 30, 2022

Eligibility Criteria

        Inclusion Criteria:

          -  diagnosed with BPD

        Exclusion Criteria:

          -  parents' rejection

Gender

All

Ages

1 Month - 3 Months

Accepts Healthy Volunteers

No

Contacts

, ,

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT03378063

Organization ID

stem cell for BPD

Responsible Party

Principal Investigator

Study Sponsor

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Collaborators

 Children's Hospital of Chongqing Medical University

Study Sponsor

, ,

Verification Date

December 2017