Brief Title
Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants
Official Title
Polymorphisms of Genes Controlling Alveolar Development and Risk of Bronchopulmonary Dysplasia
Brief Summary
Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through: 1. a genome-wide association (GWA) study in VLBW neonates, 2. a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and 3. functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).
Study Type
Observational
Primary Outcome
bronchopulmonary dysplasia
Condition
Bronchopulmonary Dysplasia
Study Arms / Comparison Groups
premature neonates
Description: gestational age less than 28 weeks
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
800
Start Date
May 2009
Eligibility Criteria
Inclusion Criteria: - Gestational age < 28 weeks - Inborn birth - Prophylactic administration of surfactant in the delivery room - Written informed consent obtained from parents Exclusion Criteria: - Gestational age of 28 weeks or more - Outborn birth - No prophylactic administration of surfactant in the delivery room - Congenital malformation - Absence of written informed consent obtained from parents
Gender
All
Ages
N/A - 8 Weeks
Accepts Healthy Volunteers
No
Contacts
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Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT00904774
Organization ID
AOR 07 018
Study Sponsor
Centre Hospitalier Intercommunal Creteil
Study Sponsor
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Verification Date
May 2009