Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants

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Bronchopulmonary dysplasia
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Brief Title

Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants

Official Title

Polymorphisms of Genes Controlling Alveolar Development and Risk of Bronchopulmonary Dysplasia

Brief Summary

      Despite considerable obstetric and neonatal advances in the care of very low birth weight
      (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of
      surviving infants, and new ways for combatting this disease must be found. BPD appears to
      result from arrested lung development, but its etiology has not yet been fully established.
      Besides the role of the exposure of the immature lung to injurious factors in the development
      of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking
      advantage of new genomic technologies, the objective of the investigators' project is to
      identify predisposing human genetic variants through:

        1. a genome-wide association (GWA) study in VLBW neonates,

        2. a candidate-gene association study, including selection of single nucleotide
           polymorphisms (SNPs) found in (a) and

        3. functional studies of any SNP found to be convincingly associated with BPD in (a) and
           (b).

Study Type

Observational

Primary Outcome

bronchopulmonary dysplasia

Condition

Bronchopulmonary Dysplasia

Study Arms / Comparison Groups

 premature neonates
Description:  gestational age less than 28 weeks

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

800

Start Date

May 2009

Eligibility Criteria

        Inclusion Criteria:

          -  Gestational age < 28 weeks

          -  Inborn birth

          -  Prophylactic administration of surfactant in the delivery room

          -  Written informed consent obtained from parents

        Exclusion Criteria:

          -  Gestational age of 28 weeks or more

          -  Outborn birth

          -  No prophylactic administration of surfactant in the delivery room

          -  Congenital malformation

          -  Absence of written informed consent obtained from parents

Gender

All

Ages

N/A - 8 Weeks

Accepts Healthy Volunteers

No

Contacts

, ,

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT00904774

Organization ID

AOR 07 018

Study Sponsor

Centre Hospitalier Intercommunal Creteil

Study Sponsor

, ,

Verification Date

May 2009