Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

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Bronchopulmonary dysplasia
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Brief Title

Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

Official Title

Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

Brief Summary

      Investigators want to learn the role of indoor environmental exposures on respiratory
      symptoms, and, separately, on lung function deficits in school-aged children with
      bronchopulmonary dysplasia (BPD).

Detailed Description

      Bronchopulmonary dysplasia (BPD) is the most common respiratory disease affecting children
      born prematurely and leads to long-term respiratory symptoms and lung function impairment
      throughout childhood. This study will, evaluate the contribution of indoor sources of
      respiratory irritants to respiratory health impairment in school-aged children with BPD.
      State-of-the-art measures of indoor air quality constituents will assess the relationship of
      nitrogen dioxide (NO2), particulate matter (PM2.5), as well as, concentrations of allergens
      (mold, mouse, cockroach, pet), endotoxin, air temperature and humidity with concurrently
      measured respiratory symptoms and lung function in a well-characterized cohort of children
      with BPD. This research will identify specific harmful components of the indoor environment
      associated with respiratory morbidity and poor lung function in children with BPD.

      Investigators will ask the participants to come in for a one time clinic visit for undergoing
      procedures as well as answering questions regarding health and home environment. During the 1
      year of participation there will also be 2 home assessment visits where investigators will
      take a sample of the home environment as well record home characteristics.

Study Type

Observational

Primary Outcome

Respiratory Morbidity

Secondary Outcome

 Lung function

Condition

Bronchopulmonary Dysplasia

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

240

Start Date

July 22, 2019

Completion Date

July 31, 2025

Primary Completion Date

July 31, 2024

Eligibility Criteria

        Inclusion Criteria:

          -  children 6-12 yrs old

          -  born <32 wks gestational age

          -  diagnosis of BPD or > 28 days of oxygen or respiratory support

        Exclusion Criteria:

          -  major airway or chest surgery

          -  physical or mental impairment that will prevent from doing spirometry

          -  plans to move out of state within the next 9 months

Gender

All

Ages

6 Years - 12 Years

Accepts Healthy Volunteers

No

Contacts

Jonathan Gaffin, MD. MMSc., 857-218-5336, [email protected]

Location Countries

United States

Location Countries

United States

Administrative Informations

NCT ID

NCT04107701

Organization ID

P00029918

Secondary IDs

R01ES030100

Responsible Party

Principal Investigator

Study Sponsor

Boston Children's Hospital

Collaborators

 National Institute of Environmental Health Sciences (NIEHS)

Study Sponsor

Jonathan Gaffin, MD. MMSc., Principal Investigator, Boston Children's Hospital

Verification Date

September 2022