Brief Title
Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD
Official Title
Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD
Brief Summary
Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).
Detailed Description
Bronchopulmonary dysplasia (BPD) is the most common respiratory disease affecting children born prematurely and leads to long-term respiratory symptoms and lung function impairment throughout childhood. This study will, evaluate the contribution of indoor sources of respiratory irritants to respiratory health impairment in school-aged children with BPD. State-of-the-art measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), as well as, concentrations of allergens (mold, mouse, cockroach, pet), endotoxin, air temperature and humidity with concurrently measured respiratory symptoms and lung function in a well-characterized cohort of children with BPD. This research will identify specific harmful components of the indoor environment associated with respiratory morbidity and poor lung function in children with BPD. Investigators will ask the participants to come in for a one time clinic visit for undergoing procedures as well as answering questions regarding health and home environment. During the 1 year of participation there will also be 2 home assessment visits where investigators will take a sample of the home environment as well record home characteristics.
Study Type
Observational
Primary Outcome
Respiratory Morbidity
Secondary Outcome
Lung function
Condition
Bronchopulmonary Dysplasia
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
240
Start Date
July 22, 2019
Completion Date
July 31, 2025
Primary Completion Date
July 31, 2024
Eligibility Criteria
Inclusion Criteria: - children 6-12 yrs old - born <32 wks gestational age - diagnosis of BPD or > 28 days of oxygen or respiratory support Exclusion Criteria: - major airway or chest surgery - physical or mental impairment that will prevent from doing spirometry - plans to move out of state within the next 9 months
Gender
All
Ages
6 Years - 12 Years
Accepts Healthy Volunteers
No
Contacts
, 857-218-5336, [email protected]
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT04107701
Organization ID
P00029918
Secondary IDs
R01ES030100
Responsible Party
Principal Investigator
Study Sponsor
Boston Children's Hospital
Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Study Sponsor
, ,
Verification Date
September 2019