Investigation of Polymorphisms in Bronchopulmonary Dysplasia In Turkish Population

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Brief Title

Investigation of Polymorphisms in Bronchopulmonary Dysplasia In Turkish Population

Official Title

Investigation of Polymorphisms Defined in Specific Genes Which Are Associated With Bronchopulmonary Dysplasia In Turkish Population

Brief Summary

      Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects a ratio of up to
      20-30% of infants prematurely born before 30rd week. Delay of starting to speak, cerebral
      palsy and cognitive disorders may be seen in infants suffering from this disease. Although
      all the evidence found on the specific mediators and pathways that regulate the mechanism by
      studies made to understand the pathophysiologic mechanism, there hasn't been any remarkable
      progress on preventing the development of BPD in new-born infants born below 1500gr body
      weight. BPD is still one of the most important morbidity and mortality reasons in premature
      infants. There is a need of further studies to understand the genetic background of BPD
      specific to different populations, to identify polymorphisms related with the disease and for
      developing genetic methods for early the diagnose of the disease.

      With this purpose, first of all polymorphisms related with BPD and those which are related
      with similar other lung diseases will be investigated. DNA samples derived from blood samples
      of 200 patients (100 BPD infant and 100 control) will be examined for polymorphisms in
      specific genes that are chosen in the light of the prior literature scanning. To the
      investigators' knowledge, this will be the first study of a broad scanning of polymorphisms
      related with BPD in Turkish population.
    

Detailed Description

      Bronchopulmonary dysplasia is a chronic lung disease that affects a ratio of up to 20-30% of
      infants prematurely born before 30rd week. Delay of starting to speak, cerebral palsy and
      cognitive disorders may be seen in infants suffering from this disease. Although all the
      evidence found on the specific mediators and pathways that regulate the mechanism by studies
      made to understand the pathophysiologic mechanism, there hasn't been any remarkable progress
      on preventing the development of BPD in new-born infants born below 1500gr body weight. BPD
      is still one of the most important morbidity and mortality reasons in premature infants.
      There is a need of further studies to understand the genetic background of BPD specific to
      different populations, to identify polymorphisms related with the disease and for developing
      genetic methods for early the diagnose of the disease.

      With this purpose, first of all polymorphisms related with BPD and those which are related
      with similar other lung diseases will be investigated. DNA samples derived from blood samples
      of 200 patients (100 BPD infant and 100 control) will be examined for polymorphisms in
      specific genes that are chosen in the light of the prior literature scanning. To the
      investigators' knowledge, this will be the first study of a broad scanning of polymorphisms
      related with BPD in Turkish population.
    


Study Type

Interventional


Primary Outcome

DNA


Condition

Bronchopulmonary Displasia

Intervention

polymorphism analyzing

Study Arms / Comparison Groups

 Study Group
Description:  Infants diagnosed with BPD.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Genetic

Estimated Enrollment

196

Start Date

July 4, 2017

Completion Date

May 24, 2018

Primary Completion Date

April 5, 2018

Eligibility Criteria

        Inclusion Criteria:

          -  infants born under 30 gestational week

          -  infants with bronchopulmonary displasia

        Exclusion Criteria:

          -  major congenital abnormalities

          -  lack of data

          -  parents don't agree with informed consent
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Seda Yilmaz Semerci, , 

Location Countries

Turkey

Location Countries

Turkey

Administrative Informations


NCT ID

NCT03467828

Organization ID

18


Responsible Party

Sponsor-Investigator

Study Sponsor

Seda Yilmaz Semerci


Study Sponsor

Seda Yilmaz Semerci, Study Chair, Kanuni Sultan Suleyman Training and Research Hospital


Verification Date

March 2019