Value of Cortactin Expression in Invasive and Non-invasive Urinary Bladder Urothelial Carcinoma in Egyptian Population

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Locally Advanced or Metastatic Urothelial Carcinoma After Failure With Platinum-Containing Chemotherapy The Cxbladder Monitoring Study Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma A Study of the Safety of Atezolizumab in Patients With Advanced or Metastatic Urothelial Carcinoma in Argentina A Clinical Study of PD-L1 Antibody ZKAB001（Drug Code） in Locally Advanced and Metastatic Urothelial Carcinoma Anti-PD(L)1 and SBRT in the Treatment of Advanced, Platinum-Refractory Urothelial Carcinoma Radium-223 and Atezolizumab in Patients With Urothelial Carcinoma With Bone Metastases Who Have Had Disease Progression After Platinum-Based Chemotherapy An Expanded Access Study of Atezolizumab in Participants With Locally Advanced or Metastatic Urothelial Carcinoma After Failure With Platinum-Containing Chemotherapy Study of Tislelizumab in Combination With Chemotherapy Compared to Chemotherapy Alone for Participants With Urothelial Carcinoma Vinflunine in Patients With Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium Application of UCAD for Diagnosing Urothelial Carcinoma. 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Brief Title

Value of Cortactin Expression in Invasive and Non-invasive Urinary Bladder Urothelial Carcinoma in Egyptian Population

Official Title

Value of Cortactin Expression in Invasive and Non-invasive Urinary Bladder Urothelial Carcinoma in Egyptian Population

Brief Summary

      Urothelial carcinoma is the ninth most common malignant neoplasm worldwide. nearly in all
      human tumors, actin filaments are involved in lamellopodia or cellular extensions. Cortactin
      is involved in fixing the actin assembly to enhance cellular penetration. Assessment of
      Cortactin expression in invasive and non-invasive urothelial carcinoma and recording any
      significant different expressions may have benefits in developing more effective anticancer
      chemotherapeutic agents.

Detailed Description

      Bladder carcinoma is the 9th most prevalent cancer worldwide. Mostcases are diagnosed in men.
      Bladder carcinoma is categorized into three disticly different categories; non- muscle
      invasive, muscle invasive and metastatic bladder carcinoma. Vast majority of all bladder
      carcinomas are diagnosed as urothelial carcinoma (UC). Squamous cell carcinoma (SCC),
      adenocarcinoma and other rare types represent the remaining 10%. In Egypt, bladder carcinoma
      is ranked as the most prevalent cancer . The most important etiological causes for such
      disease in Egypt are festation by S. haematopium and Cigarette smoking. Cortactin is a 63-65
      kDa protein, encoded by a gene located on 11q13. Cortactin activates and binds to Arp2/3 and
      stabilizes the branched Actin networks. Invadopodia are Actin-rich cellular protrusions,
      associated with enhanced proteolytic activities in the invasive regions of carcinomas. it is
      also incorporated in invadopodia, Cortactin expression is enhanced once or rapidly following
      secretions of transmembrane metalloproteinase, MT1-MMP. Extracellular matrix (ECM)
      proteolytic cleavage develops soon after secretion of MT1-MMP and Cortactin. increased
      secretion of Cortactin was studied in a lot of malignant tumors, including melanoma, mammary,
      pancreatic duct, hepatocellular and colorectal adenocarcinomas.

Study Type

Interventional

Primary Outcome

Assessment and correlating Cortactin expression in invasive and non-invasive urothelial carcinoma.

Condition

Urothelial Carcinoma

Intervention

Expression of Cortactin anti body

Study Arms / Comparison Groups

 patients with invasive and non invasive urothelial carcinoma
Description:  patients with urothelial carcinoma will be subjected to radical cystectomy or trans uretheral resection of the tumor, specimens will be sent to the pathology lab. to be examined.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Genetic

Estimated Enrollment

40

Start Date

July 1, 2021

Completion Date

January 1, 2022

Primary Completion Date

December 30, 2021

Eligibility Criteria

        Inclusion Criteria:

          -  patients with primary urinary bladder carcinoma.

        Exclusion Criteria:

          -  patients received chemotherapeutic agents.

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

, ,

Location Countries

Egypt

Location Countries

Egypt

Administrative Informations

NCT ID

NCT05070039

Organization ID

Soh-Med-21-09-44

Responsible Party

Principal Investigator

Study Sponsor

Sohag University

Study Sponsor

, ,

Verification Date

July 2022