Brief Title
RTX-224 Monotherapy in Patients With Solid Tumors
Official Title
A Phase 1/2 Study of RTX-224 for the Treatment of Patients With Advanced Solid Tumors
Brief Summary
This is an open-label, multidose, first-in-human (FIH), Phase 1/2 study of RTX-224 for the treatment of patients with relapsed or refractory (R/R), or locally advanced solid tumors.
Detailed Description
This is a Phase 1, open label, multicenter, multidose, first-in-human (FIH), dose escalation and expansion to determine the safety and tolerability, recommended phase 2 dose, and pharmacology, and antitumor activity of RTX-224 in adult patients with persistent, recurrent, or metastatic, unresectable solid tumors. The study will include a monotherapy dose escalation phase followed by an expansion phase.
Study Phase
Phase 1/Phase 2
Study Type
Interventional
Primary Outcome
Safety Assessment by rate of Adverse Events (AEs)
Secondary Outcome
Pharmacodynamics (PD) of RTX-224
Condition
Non Small Cell Lung Cancer
Intervention
RTX-224
Study Arms / Comparison Groups
RTX-224 Dose Escalation
Description: Phase 1: RTX-224 monotherapy dose escalation in Solid Tumors, administered intravenously on Day 1 of each cycle.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
7
Start Date
January 12, 2022
Completion Date
November 30, 2022
Primary Completion Date
November 30, 2022
Eligibility Criteria
Inclusion Criteria: - Signed written informed consent obtained prior to study procedures Patients ≥18 years with an ECOG of 0 or 1 - R/R, or locally advanced, unresectable, and histologically or cytologically confirmed (a) NSCLC, (b) cutaneous melanoma, (c) HNSCC, (d) UC, or (e) TNBC, which are refractory to or otherwise ineligible for treatment with standard-of-care treatments - Prior therapy in each disease setting must include the following: - NSCLC: Patients must have experienced disease progression following platinum-containing chemotherapy and a PD-1 or PD-L1 inhibitor. Patients with EGFR, ALK, ROS-1, or other actionable mutations should have previously received or been ineligible for therapies targeting their respective mutation(s). - Cutaneous melanoma: Patients must have experienced disease progression following a PD-1 or PD-L1 inhibitor. Patients with V600E mutations should have previously received or been ineligible for approved BRAF inhibitor or MEK inhibitor therapy. - HNSCC: Patients must have experienced disease progression following platinum-based combination chemotherapy and a PD-1 or PD-L1 inhibitor. - UC: Patients must have experienced disease progression following platinum-based combination chemotherapy and a PD-1 or PD-L1 inhibitor. - TNBC: Patients must have experienced disease progression following single-agent or combination chemotherapy. Patients with BRCA1/2 mutations should have previously received or been ineligible for an approved PARP inhibitor; patients who are PD-L1 positive should have received or been ineligible for an approved PD-1 or PD-L1 inhibitor. - Disease must be measurable per Response Evaluation Criteria - The shorter of 28 days or 5 half-lives must have elapsed since the completion of prior therapy, before initiation of study treatment. - Adequate Organ Function as Defined by the protocol: - AST and ALT ≤3 × the upper limit of normal (ULN) Except in documented cases of Gilbert syndrome, total bilirubin ≤1.5 × ULN - Serum albumin ≥2.5 g/dL - Serum or plasma creatinine ≤1.5 × ULN and/or glomerular filtration rate ≥50 mL/min/1.73 calculated by the Cockcroft-Gault formula - Absolute neutrophil count ≥1 × 103/μL - Platelet count ≥100 × 103/μL - Hemoglobin ≥9 g/dL Exclusion Criteria: - Patient has central nervous system (CNS) involvement. If the patient fulfills the following 3 criteria, she/he is eligible for the trial after consultation with the Sponsor Medical Monitor. - Completed prior therapy for CNS metastases (radiation and/or surgery) - CNS tumor(s) is clinically stable at the time of enrollment - Patient does not require corticosteroid or antiepileptic therapy for management of CNS metastases - Known hypersensitivity to any component of study treatment or excipients. - Positive antibody screen using institution's standard type and screen test. - Clinically significant, active and uncontrolled infection, including human immunodeficiency virus (HIV), Hepatitis B virus (HBV), or Hepatitis C virus (HCV).
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
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Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT05219578
Organization ID
RTX-224-01
Responsible Party
Sponsor
Study Sponsor
Rubius Therapeutics
Study Sponsor
, ,
Verification Date
December 2022