Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy

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Brief Title

Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy


Brief Summary

      OBJECTIVES: I. Determine the response in plasma norepinephrine concentration and plasma
      glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic
      receptor in 6 patients with regional lipoatrophy and in 6 controls.

      II. Determine the full sequence of the alpha-2 adrenergic receptor structural gene in genomic
      DNA from peripheral blood leukocytes.
    

Detailed Description

      PROTOCOL OUTLINE: Antihypertensives are held, beginning 3 days before the first study day.

      An oral challenge is administered as follows: clonidine on day 1, yohimbine on day 2. The
      order of administration is reversed in alternate subjects.

      Timed measurements of norepinephrine, glycerol, and free fatty acids follow each challenge.
      Structural gene sequencing is evaluated for each participant.
    


Study Type

Observational




Condition

Lipodystrophy



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

12

Start Date

November 1999



Eligibility Criteria

        PROTOCOL ENTRY CRITERIA:

        --Disease Characteristics-- Clinical diagnosis of regional lipoatrophy Control subjects:
        Women aged 18 to 65 Weight 90% to 150% of ideal No significant acute or chronic illness
        --Patient Characteristics-- Negative pregnancy test required of fertile women
      

Gender

Female

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Fannie Smith, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00004329

Organization ID

199/11884

Secondary IDs

UTMB-437


Study Sponsor

National Center for Research Resources (NCRR)

Collaborators

 University of Texas

Study Sponsor

Fannie Smith, Study Chair, University of Texas


Verification Date

December 2003