Online Response Inhibition Training for Trichotillomania

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Brief Title

Online Response Inhibition Training for Trichotillomania

Official Title

Developing Online Response Inhibition Training for Individuals With Trichotillomania

Brief Summary

      Trichotillomania (TTM) remains one of the most poorly-understood and inadequately-treated
      conditions. Research has shown poor response inhibition (RI; the ability to inhibit
      inappropriate but potent response) as an important cognitive feature of TTM. Investigators
      have developed a computerized training program that aims to improve RI. Fifty children with
      TTM will be randomly assigned to (a) online 8-session RI training (n=25), or (b) 1-month
      waitlist condition (n = 25), and will be assessed at baseline, post-treatment, and 1-month
      follow-up. Investigators hypothesize that the online RIT will show greater improvement in TTM
      symptoms and RI capabilities at post-treatment and 1-month follow-up assessments, compared to
      the waitlist condition. This study will help develop an effective cognitive intervention
      program for TTM.
    

Detailed Description

      Although trichotillomania (TTM), an impulse control disorder characterized by compulsive hair
      pulling, typically results in serious consequences including impaired individual functioning,
      medical problems (e.g., skin infections), and elevated comorbidity with other psychiatric
      disorders, it remains one of the most poorly-understood and inadequately-treated psychiatric
      conditions. There is an urgent need for effective and accessible clinical interventions for
      TTM, especially for young individuals who suffer from a marked lack of adequate treatment
      resources despite the early onset of the condition. One promising therapeutic approach is to
      improve cognitive problems believed to contribute to TTM, using a computerized cognitive
      retraining method. Research has indicated impaired response inhibition (RI; the ability to
      inhibit inappropriate but potent response) as an important cognitive feature underlying TTM.
      Therefore, RI is considered to be an important target of cognitive retraining. Investigators
      have developed a computerized training program that aims to improve RI capabilities in the
      format of an online video game. Fifty children with TTM will be randomly assigned to (a)
      online 8-session RIT (n=25), or (b) 1-month waitlist condition (n = 25), and will be assessed
      at baseline, post-treatment, and 1-month follow-up. The waitlisted participants will also be
      invited to undergo the training program after the 1-month follow-up assessment is completed.
      Investigators hypothesize that the online RIT will show greater improvement in TTM symptoms
      and RI capabilities at post-treatment and 1-month follow-up assessments, compared to the
      waitlist condition. This study is expected to generate important data that will guide the
      development of an accessible, cost-efficient, and effective cognitive intervention for
      individuals suffering from TTM.
    


Study Type

Interventional


Primary Outcome

Change on the NIMH Trichotillomania Severity and Impairment Scales

Secondary Outcome

 Change on the Clinical Global Impression Scale

Condition

Trichotillomania

Intervention

Online cognitive training

Study Arms / Comparison Groups

 Online cognitive training
Description:  Online cognitive training will provides eight sessions of a computerized training game. Each session will last about 30-40 minutes, and participants will undergo 2 sessions each week over a 4-week period.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Behavioral

Estimated Enrollment

54

Start Date

November 2013

Completion Date

June 2017

Primary Completion Date

June 2017

Eligibility Criteria

        Inclusion Criteria:

          -  age between 8 and 17

          -  a diagnosis of trichotillomania

          -  a computer with high speed internet

        Exclusion Criteria:

          -  current substance use problems

          -  current or past psychotic disorder, bipolar disorder, or schizophrenia

          -  current behavioral treatments for trichotillomania

          -  significant suicidality

          -  severe conditions known for poor response inhibition(ADHD, OCD, and tic disorders)

          -  recent or planned change in medication

          -  low intellectual functioning (below 80)
      

Gender

All

Ages

8 Years - 17 Years

Accepts Healthy Volunteers

No

Contacts

Hanjoo Lee, Ph.D., , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT01984333

Organization ID

UWMRF-133


Responsible Party

Principal Investigator

Study Sponsor

University of Wisconsin, Milwaukee


Study Sponsor

Hanjoo Lee, Ph.D., Principal Investigator, University of Wisconsin, Milwaukee


Verification Date

October 2017