Brief Title
N-Acetyl Cysteine in Trichotillomania
Official Title
A Double-Blind, Placebo-Controlled Study of N-Acetyl Cysteine in Trichotillomania
Brief Summary
This is a 12-week, double-blind study of N-Acetyl Cysteine in the treatment of trichotillomania
Detailed Description
The goal of the proposed study is to evaluate the efficacy and safety of N-Acetyl Cysteine (NAC) in trichotillomania. Forty subjects with DSM-IV trichotillomania will receive 12 weeks of double-blind NAC or placebo. The hypothesis to be tested is that NAC will be effective and well tolerated in patients with trichotillomania compared to placebo. The proposed study will provide needed data on the treatment of a disabling disorder that currently lacks a clearly effective treatment.
Study Phase
Phase 2
Study Type
Interventional
Primary Outcome
Massachusetts General Hospital Hairpulling Scale
Condition
Trichotillomania
Intervention
Placebo
Study Arms / Comparison Groups
N-Acetyl Cysteine
Description: N-Acetyl Cysteine
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
50
Start Date
July 2006
Completion Date
September 2008
Primary Completion Date
September 2008
Eligibility Criteria
Inclusion Criteria: - men and women age 18-65; - current DSM-IV trichotillomania Exclusion Criteria: - unstable medical illness; - history of seizures; - myocardial infarction within 6 months; - current pregnancy or lactation, or inadequate contraception in women of childbearing potential; - any thoughts of suicide; - lifetime history of DSM-IV bipolar disorder type I, dementia, or schizophrenia or any other DSM-IV psychotic disorder; - previous treatment with N-Acetyl Cysteine; - treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline; - 9) diagnosis of asthma
Gender
All
Ages
18 Years - 65 Years
Accepts Healthy Volunteers
No
Contacts
Jon E Grant, MD, JD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00354770
Organization ID
0604M85110
Responsible Party
Principal Investigator
Study Sponsor
University of Chicago
Study Sponsor
Jon E Grant, MD, JD, Principal Investigator, University of Minnesota
Verification Date
October 2016