Methylphenidate in ADHD With Trichotillomania

Learn more about:
Related Clinical Trial
Technology Assisted Treatment for Trichotillomania Leveraging Technological Advancements to Improve the Treatment of Trichotillomania Internet CBT for Trichotillomania and Skin Picking Disorder Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals Evaluation of a Brief Surf the Urge Intervention Feasibility Study for Treating Trichotillomania With Wearable Device and App System Cognitive Behavioral Treatment of Pediatric Trichotillomania Telepsychotherapy for the Treatment of Adolescents With Trichotillomania Stepped Care in the Treatment of Trichotillomania Response Inhibition Training for Individuals With Trichotillomania Cognitive Behavioral Therapy for Trichotillomania Examining Behavior Therapy for Trichotillomania in Children and Adolescents Comprehensive Behavioral (ComB) Model of Treatment for Trichotillomania Methylphenidate in ADHD With Trichotillomania Marinol in Trichotillomania or Obsessive Compulsive Disorder Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder) Olanzapine in the Treatment of Hair Pulling (Trichotillomania) A Study in Patients With Trichotillomania Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania Inositol in Trichotillomania Trial of Aripiprazole in Trichotillomania Habit Reversal Training for Children and Adolescents With Trichotillomania Naltrexone in the Treatment of Trichotillomania N-Acetylcysteine for Pediatric Trichotillomania Online Response Inhibition Training for Trichotillomania N-Acetyl Cysteine in Trichotillomania Trichotillomania: Group Cognitive-Behavioral Therapy Efficacy of COMB (Comprehensive Behavioral) Model of Treatment of Trichotillomania Milk Thistle in Trichotillomania in Children and Adults Cognitive Behavioral Group Therapy for Trichotillomania (Hair Pulling Disorder) Testing a New Therapy for Trichotillomania Online Treatment of Trichotillomania

Brief Title

Methylphenidate in ADHD With Trichotillomania

Official Title

Methylphenidate Treatment of Children and Adolescents Diagnosed With ADHD and Its Influence on Comorbid Trichotillomania

Brief Summary

      This study will evaluate the safety and effectiveness of methylphenidate in treating
      attention deficit hyperactivity disorder (ADHD) in children with both ADHD and

      Trichotillomania is an impulse control disorder. There is growing evidences of the
      involvement of dopaminergic neurotransmission in the pathophysiology of trichotillomania.
      Reported increase in the prevalence of ADHD among patients with impulse control disorders,
      such as pathological gambling as well as trichotillomania, may result from the overlapping
      pathophisiological background. It is hypothesized that in cases of ADHD comorbid with
      trichotillomania methtylphenidate treatment will exhibit beneficial effects in both the ADHD
      and the hair pulling.

Detailed Description

      Thirty children and adolescents aged 6-18 years, diagnosed with ADHD and trichotillomania,
      will receive MPH monotherapy treatment for a period of 12 weeks, targeting both ADHD and
      trichotillomania symptoms as rated by the ADHD- rating scale (ADHD-RS) and by the
      Massachusetts General Hospital Hair Pulling Scale and Clinical Global Impression-Severity
      (CGI) scale. The rating scales will be assessed at baseline and at the endpoint (after 12
      weeks).The side effects will be monitored via weekly spontaneous self reports by each
      participant. All results will be expressed as mean ±SD. Student's paired t-test and ANOVA
      test will be used as appropriate.

Study Phase

Phase 4

Study Type


Primary Outcome

Clinicial administered Massachusetts General Hospital Hair Pulling Scale for trichotillomania

Secondary Outcome

 Clinicial administered ADHD Rating Scale Clinical Global Impressions (CGI) scale for ADHD severity Weekly spontaneous self report of side effects






* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

October 2007

Completion Date

October 2009

Eligibility Criteria

        Inclusion Criteria:

          -  DSM-IV Diagnosis of trichotillomania

          -  DSM-IV diagnosis of ADHD

          -  Has not taken stimulants or alpha-adrenergic medications for more than 2 weeks prior
             to entering the study.

        Exclusion Criteria:

          -  History of moderate or severe adverse event, related to MPH

          -  History of any psychotic disorder

          -  Current drug abuse, acute psychotic or affective disorder




6 Years - 18 Years

Accepts Healthy Volunteers



Pavel Golubchik, M.D., +972-3-925-8270, [email protected]

Location Countries


Location Countries


Administrative Informations



Organization ID


Secondary IDs


Study Sponsor

Geha Mental Health Center


 Clalit Health Services

Study Sponsor

Pavel Golubchik, M.D., Principal Investigator, Geha Mental Health Center

Verification Date

October 2007