Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania

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Brief Title

Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania

Official Title

Developing Effective Response Inhibition Training for Symptom Relief in Obsessive-Compulsive and Related Disorders and Trichotillomania

Brief Summary

      Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are
      characterized by the marked difficulty in inhibiting unwanted or inappropriate responses.
      There is compelling evidence that poor response inhibition is a core cognitive feature of OCD
      and its related disorders, but no effective intervention exists that directly attempts to
      address this problematic cognitive deficiency. This study will examine the feasibility and
      clinical utility of a computerized cognitive training program designed to improve response
      inhibition among individuals diagnosed with OCD or trichotillomania.This training program
      offers systematic practice of response inhibition in the form of a 40-level computer game.
      Individuals with these conditions will be randomized to either 8 sessions of (a) computerized
      response inhibition training (RIT) or (b) placebo computer training (PLT). We hypothesize
      that RIT will outperform PLT in improving response inhibition capabilities and reducing
      relevant clinical symptoms. In sum, this project is expected to generate important knowledge
      to guide the development of effective computer-based treatment approaches that may help
      reduce critical problems of existing treatments such as suboptimal patient retention and
      treatment under-utilization, thereby improving overall treatment response rates among
      individuals suffering from OCD and related conditions.

Study Type


Primary Outcome

Composite Score of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and National Institute of Mental Health (NIMH)

Secondary Outcome

 Clinical Global Impression Severity and Improvement


Obsessive Compulsive Disorder


Response inhibition training

Study Arms / Comparison Groups

 Response inhibition training
Description:  Eight 45-minute sessions of computerized training on response inhibition over a 4 week period


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

August 2014

Completion Date

August 2017

Primary Completion Date

August 2017

Eligibility Criteria

        Inclusion Criteria:

          -  Principal diagnosis of obsessive-compulsive disorder or trichotillomania

        Exclusion Criteria:

          -  Current substance use problems

          -  Current/Past Psychotic disorder, bipolar disorder, or schizophrenia

          -  Attention deficit/hyperactivity disorder or tic disorder

          -  Severe depressive symptoms

          -  Current psychotherapy

          -  Current suicidality

          -  Estimated intellectual functioning < 80

          -  Lack of response inhibition deficits on a stop-signal task




18 Years - 60 Years

Accepts Healthy Volunteers



Han Joo Lee, Ph.D., , 

Location Countries

United States

Location Countries

United States

Administrative Informations



Organization ID


Secondary IDs


Responsible Party

Principal Investigator

Study Sponsor

University of Wisconsin, Milwaukee


 National Institute of Mental Health (NIMH)

Study Sponsor

Han Joo Lee, Ph.D., Principal Investigator, University of Wisconsin, Milwaukee

Verification Date

August 2018