Brief Title
Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania
Official Title
Developing Effective Response Inhibition Training for Symptom Relief in Obsessive-Compulsive and Related Disorders and Trichotillomania
Brief Summary
Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are
characterized by the marked difficulty in inhibiting unwanted or inappropriate responses.
There is compelling evidence that poor response inhibition is a core cognitive feature of OCD
and its related disorders, but no effective intervention exists that directly attempts to
address this problematic cognitive deficiency. This study will examine the feasibility and
clinical utility of a computerized cognitive training program designed to improve response
inhibition among individuals diagnosed with OCD or trichotillomania.This training program
offers systematic practice of response inhibition in the form of a 40-level computer game.
Individuals with these conditions will be randomized to either 8 sessions of (a) computerized
response inhibition training (RIT) or (b) placebo computer training (PLT). We hypothesize
that RIT will outperform PLT in improving response inhibition capabilities and reducing
relevant clinical symptoms. In sum, this project is expected to generate important knowledge
to guide the development of effective computer-based treatment approaches that may help
reduce critical problems of existing treatments such as suboptimal patient retention and
treatment under-utilization, thereby improving overall treatment response rates among
individuals suffering from OCD and related conditions.
Study Type
Interventional
Primary Outcome
Composite Score of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and National Institute of Mental Health (NIMH)
Secondary Outcome
Clinical Global Impression Severity and Improvement
Condition
Obsessive Compulsive Disorder
Intervention
Response inhibition training
Study Arms / Comparison Groups
Response inhibition training
Description: Eight 45-minute sessions of computerized training on response inhibition over a 4 week period
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Behavioral
Estimated Enrollment
45
Start Date
August 2014
Completion Date
August 2017
Primary Completion Date
August 2017
Eligibility Criteria
Inclusion Criteria:
- Principal diagnosis of obsessive-compulsive disorder or trichotillomania
Exclusion Criteria:
- Current substance use problems
- Current/Past Psychotic disorder, bipolar disorder, or schizophrenia
- Attention deficit/hyperactivity disorder or tic disorder
- Severe depressive symptoms
- Current psychotherapy
- Current suicidality
- Estimated intellectual functioning < 80
- Lack of response inhibition deficits on a stop-signal task
Gender
All
Ages
18 Years - 60 Years
Accepts Healthy Volunteers
No
Contacts
Han Joo Lee, Ph.D., ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT02059980
Organization ID
R21-RIT_OC-LEE
Secondary IDs
R21MH094537
Responsible Party
Principal Investigator
Study Sponsor
University of Wisconsin, Milwaukee
Collaborators
National Institute of Mental Health (NIMH)
Study Sponsor
Han Joo Lee, Ph.D., Principal Investigator, University of Wisconsin, Milwaukee
Verification Date
August 2018