Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

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Country Product Indication Sponsor Date
Cinacalcet Parathyroid carcinoma Amgen, Inc.;One Amgen Center Drive;Thousand Oaks, California, 91320 May 12, 2003
Recombinant T-cell receptor ligand Multiple sclerosis patients who are both HLA-DR2 positive and autoreactive to myelin oligodendrocyte glycoprotein residues 35-55 Artielle ImmunoTherapeutics, Inc.;9020 SW Washington Square Road, Suite 450;Tigard,, Oregon, 97223 May 2, 2003
Capsaicin Painful HIV-associated neuropathy Acorda Therapeutics, Inc.;420 Saw Mill River Road;Ardsley, New York, 10502 May 2, 2003
DHA-paclitaxel Adenocarcinoma of the stomach or lower esophagus Luitpold Pharmaceuticals, Inc.;One Luitpold Drive, P. O. Box 9001;Shirley, New York, 11967 May 1, 2003
Tretinoin T-cell lymphoma Antigenics, Inc.;3 Forbes Road;Lexington, Massachusetts, 02421 April 11, 2003
4,5-dibromorhodamine 123 Chronic myeloid leukemia Kiadis Pharma Canada, Inc.;2525 Marie-Curie, Saint-Laurent (Quebec) H4S 2E1; April 10, 2003
Alendronate Osteogenesis imperfecta Merck, Sharpe & Dohme Corp.;126 East Lincoln Ave., RY 33-212;Rahway, New Jersey, 07065 March 31, 2003
Sodium pyruvate Cystic fibrosis Cellular Sciences, Inc;84 park Avenue, P.O. Box 968;Flemington, New Jersey, 08822 March 31, 2003
(+/-)-7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid Prevention of serious adverse events associated with vascular leak syndrome caused by Interleukin-2 therapy Intarcia Therapeutics, Inc.;24650 Industrial Blvd;Hayward, California, 94545 March 31, 2003
Dextran 1 Cystic fibrosis BCY LifeSciences Inc.;160 Eglinton Ave. East, Suite 600;Toronto, Ontario M4P 3B March 21, 2003
Antisense 20-mer phosphorothioate oligonucleotide [complementary to the coding region of R2 component of the human ribonucleotide reductase mRNA] Renal cancer Lorus Therapeutics, Inc;2 Meridan Road, M9W427; March 12, 2003
MaxAdFVIII Hemophilia A GenStar Therapeutics Corporation;10865 Altman Row, Suite 200;San Diego, California, 92121 March 3, 2003
Anti-CD23 IgG1, kappa monoclonal antibody Chronic lymphocytic leukemia Biogen IDEC, Inc.;5200 Research Place;San Diego, California, 92122 February 12, 2003
Ecallantide Angioedema Dyax Corp.;300 Shire Way;Lexington, Massachusetts, 02421 February 4, 2003
Replication defective recombinant adenovirus serotype 5 vector carrying the p53 gene in its E1 deleted region Squamous cell carcinoma of head and neck Introgen Therapeutics, Inc.;2250 Holcombe Blvd;Houston, Texas, 77030 January 27, 2003
Tezacitabine Adenocarcinoma of the esophagus and stomach Sanofi-Aventis US, Inc.;9 Great valley Parkway;Malvern, Pennsylvania, 19355 January 27, 2003
Alteplase Intraventricular hemorrhage associated with intracerebral hemorrhage Daniel F. Hanley, MD;Johns Hopkins University, 600 N. Wolfe St., Jefferson 1-109;Baltimore, Maryland, 21287 January 27, 2003
A-Galactosidase A Fabry disease iBio, Inc.;9 Innovation Way, Suite 100;Newark, Delaware, 19711 January 21, 2003
Mafosfamide Neoplastic meningitis Baxter Healthcare Corporation;Route 120 & Wilson Road;Round Lake, Illinois, 60073 January 21, 2003
Bifidobacterium longum infantis 35624 pediatric Crohn’s disease Alimentary Health Limited;Guardwell, Kinsale;County Cork January 16, 2003
Human Anti-tumor Necrosis factor alpha monoclonal antibody Uveitis of the posterior segment of non-infectious etiology, and uveitis of the anterior segment of non-infectious etiology and refractory to conventional therapy Centocor, Inc.;200 Great Valley Parkway;Malvern, Pennsylvania, 19355 January 16, 2003
Bortezomib Multiple myeloma Millennium Pharmaceuticals, Inc.;40 Landsdowne Street;Cambridge, Massachusetts, 02139 January 15, 2003
2′,3′,5′-tri-o-acetyluridine Mitochondrial disease Repligen Corporation;41 Seyon Street, Building 1, Suite 100;Waltham, Massachusetts, 02453 January 13, 2003
R-etodolac Chronic lymphocytic leukemia Cephalon, Inc.;41 Moores Road;Frazer, Pennsylvania, 19355 December 9, 2002
Civamide Postherpetic neuralgia of the trigeminal nerve Winston Laboratories, Inc.;100 Fairway Drive, Suite 134;Vernon Hills, Illinois, 60061 December 9, 2002