Rehovot, Israel – Researchers from Israel identified novel small molecules that can selectively lower the levels of mutant Huntington (Htt) mRNA and protein in Huntington disease (HD). These molecules reduced mitochondrial dysfunction, restored the expression of brain-derived neurotrophic factor (BDNF), improved motor function, and reduced anxious-like behavior in a mouse model...
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Boston, Mass. — In the development of Parkinson’s disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms. But without a test that can detect these changes, it’s difficult to intervene early to more effectively slow disease progression. To address...
ROOT, Switzerland — NovoCure Ltd. (NASDAQ: NVCR) today announced that the final patient has been enrolled in the global phase 3 TRIDENT clinical trial evaluating the safety and efficacy of initiating Optune Gio® (formerly known as Optune®) concurrent with radiation therapy and temozolomide (TMZ) for the treatment of adult patients...
BOSTON, Mass. — Novotech, the global full-service clinical Contract Research Organization (CRO) that partners with biotech companies to accelerate the development of advanced and novel therapeutics at every phase, has released today an industry-leading report on Duchenne Muscular Dystrophy (DMD) Clinical Trial Landscape. The report includes emerging genetic therapies, funding...
PITTSBURGH, PA— The current standard of care for treating patients with stage 3 colorectal cancer is to use adjuvant therapy with FOLFOX, a combination of the drugs fluorouracil, leucovorin, and oxaliplatin. Although effective, the use of oxaliplatin can lead to known adverse events, mainly neurotoxicity that may be chronic. NRG...
The NRG Oncology clinical trial NRG-LU002 comparing local consolidative therapy (LCT) and maintenance systemic therapy to maintenance systemic therapy alone for limited-metastatic non-small cell lung cancer (NSCLC) recently reached the trial’s accrual goal for the Phase 2 portion of the study. The trial is expected to remain closed for required...
PARAMUS, N.J. — NS Pharma, Inc., a subsidiary of Nippon Shinyaku Co., Ltd., announced that, on December 13, 2023, the European Commission (EC) has granted orphan drug designation for NS-089/NCNP-02, which is being developed for the treatment of Duchenne muscular dystrophy (Duchenne), a rare and deadly genetic disorder that occurs...
Singapore – A team of international researchers at the University of Oxford (Oxford) and Nanyang Technological University, Singapore (NTU Singapore), has discovered a new process for repairing damaged DNA that is particularly relevant for patients undergoing colorectal cancer treatments. Reporting their finding in Cell, the researchers describe a new process...
SINGAPORE – Immunotherapy is a type of cancer treatment that uses the body’s own immune system to help fight cancer. This is by stimulating the immune response to recognise and attack cancer cells more effectively. The treatment involves using substances that boost the immune system, teaching immune cells to target...
Singapore – In a breakthrough for the advanced study of gut health, scientists from the National University of Singapore (NUS) have developed a 3D microscopic version of the human intestines condensed into a small chip about half the size of a five-cent coin. This new cell culturing platform, known as the...