Venous Thromboembolism in DM1

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Brief Title

Venous Thromboembolism in DM1

Official Title

Incidence and Predictors of Venous Thromboembolism in Myotonic Dystrophy

Brief Summary

      The risk for venous thromboembolism (VTE) in DM1 and in other inherited myopathies, which can
      lead to chronic immobilization, are unknown. The purpose of this study is to evaluate
      incidence of VTE in cohort of patients presenting with DM1 with a comparison to a group of
      other inheritable myopathies and to a community-based population.
    

Detailed Description

      A cohort of more that 2,800 adult patients admitted to our Institutions between January 2000
      and November 2014 with genetically proven myopathy will be retrospectively included.

      Any information relative to their demographic and genetic characteristics, their muscular
      functional status and the occurrence of VTE will be collected.

      Statistical analysis will be performed to estimate the incidence of venous thromboembolism in
      this population, to identify predictors of VTE, and to compare its incidence to a
      community-based population.
    


Study Type

Observational


Primary Outcome

Any episode of pulmonary embolism and/or deep vein thrombosis, diagnosed according to 2011 AHA guidelines on venous thromboembolism management


Condition

Venous Thromboembolism



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

2810

Start Date

January 2000

Completion Date

January 2017

Primary Completion Date

November 2014

Eligibility Criteria

        Inclusion Criteria:

          -  Age > 18 years

          -  Genetically proven myopathy

          -  Admission in our institutions from January 2000 to November 2014

        Exclusion Criteria:

          -  Patient refusal
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Karim Wahbi, MD, PhD, , 



Administrative Informations


NCT ID

NCT03141749

Organization ID

Institutmyologie


Responsible Party

Sponsor

Study Sponsor

Institut de Myologie, France


Study Sponsor

Karim Wahbi, MD, PhD, Principal Investigator, Institut de Myologie, Paris, FRANCE


Verification Date

May 2017