Effects of a 12-week Strength Training Program in Men With Myotonic Dystrophy Type 1

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Brief Title

Effects of a 12-week Strength Training Program in Men With Myotonic Dystrophy Type 1

Official Title

Effects of a 12-week Strength Training Program in Men With Myotonic Dystrophy Type 1

Brief Summary

      Eleven men with myotonic dystrophy type 1 (DM1) underwent a 12-week lower-limb strength
      training program. The training program consisted of 3 series of 6 to 8 maximal repetitions of
      5 different exercises: Leg extension, leg press, hip abduction, squat and plantar flexion.
      Training sessions were closely supervised and took place twice a week. It is hypothesised
      that the training program will induce muscular hypertrophy despite the genetic defect. The
      training program should also have positive effects on function. The participants were
      evaluated at baseline, week 6, week 12, month 6 and month 9 to see the effects of the
      training program and if these effects are maintained over time.
    



Study Type

Interventional


Primary Outcome

Changes in maximal isometric muscle strength of the knee extensors

Secondary Outcome

 Changes in maximal isometric muscle strength of the knee flexors

Condition

Myotonic Dystrophy 1

Intervention

Training program

Study Arms / Comparison Groups

 Training program
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

11

Start Date

July 1, 2017

Completion Date

June 22, 2018

Primary Completion Date

June 22, 2018

Eligibility Criteria

        Inclusion Criteria:

          -  DM1 diagnosis must be confirmed by genetic analysis;

          -  Male gender, aged between 30 and 65 years old;

          -  Be able to walk without assistance;

          -  Consent of the neurologist must be given to participate in this study;

          -  Must reside in the Saguenay-Lac-St-Jean region;

          -  Subjects must be able to give their consent freely and voluntarily.

        Exclusion Criteria:

          -  Patients with any other form of muscular dystrophy are excluded;

          -  Any contraindication for strenuous exercise or muscle biopsy.
      

Gender

Male

Ages

30 Years - 65 Years

Accepts Healthy Volunteers

No

Contacts

Elise Duchesne, Ph.D., , 

Location Countries

Canada

Location Countries

Canada

Administrative Informations


NCT ID

NCT04018820

Organization ID

2017-005


Responsible Party

Sponsor-Investigator

Study Sponsor

Élise Duchesne

Collaborators

 Fondation du Grand défi Pierre Lavoie

Study Sponsor

Elise Duchesne, Ph.D., Principal Investigator, Université du Québec à Chicoutimi


Verification Date

December 2021