Myotonic Dystrophy Type 1 and Resistance Exercise

Brief Title

Myotonic Dystrophy Type 1 and Resistance Exercise

Official Title

Recovery After Moderate-Heavy Resistance Exercise in Myotonic Dystrophy Type 1-patients

Brief Summary

      The purpose of this study is to investigate the response after one bout of moderate-heavy
      resistance exercise in patients suffering from Myotonic Dystrophy type 1. There is still
      doubt about if these patients could benefit from resistance exercise, or if this mode of
      exercise is detrimental to their mobility and health. We aim to monitor the subjects during
      the recovery phase and investigate recovery in several ways.
    

Detailed Description

      Myotonic dystrophy type 1 (DM1) is an autosomal, dominantly inherited, muscular disease and
      the most common muscular dystrophy amongst adults. The disease is characterized by
      progressive myopathy and myotonia, first evident in the distal parts of the body: calves and
      forearms, further progressing towards proximal parts. A recent review by Voet and co-workers
      (2013) concludes that exercise is safe for DM1-patients, and based on our current knowledge,
      DM1-patients should be able to gain positive adaptations from exercise. However, the
      physiological outcomes of an exercise stimulus are not well studied in this population and
      because of alterations in important Ca2+ handling systems the recovery processes might be
      significantly different from healthy muscles.

      The aim of this study is to investigate the acute responses to moderate-heavy resistance
      exercise in DM1-patients. We aim to establish a timeline for recovery of muscle strength,
      measured as maximal voluntary contraction. In line with this, we want to investigate if any
      muscular damage has occurred with both direct and indirect measures, and possible mechanisms
      leading to muscle damage, i.e. impaired Ca2+ handling.
    

Study Type

Interventional

Primary Outcome

Change in muscle strength

Secondary Outcome

 Muscle protein synthesis rate

Condition

Myotonic Dystrophy 1

Intervention

Moderate-Heavy Resistance Exercise

Study Arms / Comparison Groups

 DM1-Ex

Description:  Moderate-heavy resistance exercise of one leg in DM1-patients

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Status

Other

Estimated Enrollment

32

Start Date

June 14, 2021

Completion Date

March 2022

Primary Completion Date

March 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Confirmed Myotonic Dystrophy type 1-diagnosis

        Exclusion Criteria:

          -  Non-ambulatory

          -  Injuries to muscle-skeletal-system that prevents resistance exercise

          -  Severe affection of the cardiovascular system

          -  Cognitive affection

          -  Lives more than one hour from test site
      

Gender

All

Ages

18 Years - 40 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Truls Raastad, PhD, +47 23 26 23 28, [email protected]

Location Countries

Norway

Location Countries

Norway

NCT ID

NCT05036447

Organization ID

STYRK DM1

Responsible Party

Principal Investigator

Study Sponsor

Norwegian School of Sport Sciences

Collaborators

 Oslo University Hospital

Study Sponsor

Truls Raastad, PhD, Principal Investigator, Norwegian School of Sport Sciences

Verification Date

August 2021