Brief Title
SU5416 in Treating Patients With Malignant Mesothelioma
Official Title
A Phase II Trial of SU5416 (NSC# 696819) in Patients With Malignant Mesothelioma
Brief Summary
Phase II trial to study the effectiveness of SU5416 in treating patients who have malignant
mesothelioma. SU5416 may stop the growth of malignant mesothelioma by stopping blood flow to
the tumor.
Detailed Description
OBJECTIVES:
I. Determine the objective response rate, median and overall survival, and time to
progression in patients with unresectable malignant mesothelioma treated with SU5416.
II. Determine the effect of SU5416 on surrogate biologic endpoints, including microvessel
density, tissue proliferative index, apoptosis, vascular endothelial growth factor levels,
and tumor perfusion measured by MRI in these patients.
III. Determine the toxicity of this regimen in these patients.
OUTLINE: This is a multicenter study.
Patients receive SU5416 IV over 1 hour twice weekly. Courses repeat every 4 weeks for a
minimum of 2 courses in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: Approximately 21-45 patients will be accrued for this study within 18-24
months.
Study Phase
Phase 2
Study Type
Interventional
Condition
Malignant Mesothelioma
Intervention
semaxanib
Study Arms / Comparison Groups
Arm I
Description: Patients receive SU5416 IV over 1 hour twice weekly. Courses repeat every 4 weeks for a minimum of 2 courses in the absence of disease progression or unacceptable toxicity.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
45
Start Date
August 2000
Completion Date
February 2009
Primary Completion Date
February 2007
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Histologically or cytologically proven malignant mesothelioma (epithelial,
sarcomatoid, or mixed subtype) that is not amenable to surgery or radiotherapy
- Measurable disease
- At least 20 mm by conventional techniques or at least 10 mm by spiral CT scan
- Pleural effusions and ascites are not considered measurable lesions
- Only site of measurable disease must not be located within prior radiotherapy port
- Lesion must be accessible for biopsy
- History of previously treated CNS metastasis allowed if:
- Neurologically stable
- No requirement for IV or oral steroids or IV anticonvulsants
- No active or residual disease by brain CT or MRI scan
- Patients with neurologic signs or symptoms suggestive of CNS metastasis must have a
negative brain CT or MRI scan
PATIENT CHARACTERISTICS:
- Age: 18 and over
- Performance status: WHO 0-2
- Life expectancy: At least 12 weeks
- WBC at least 3,000/mm3
- Platelet count at least 75,000/mm3
- Bilirubin no greater than 1.5 mg/dL
- SGOT and SGPT no greater than 2.5 times upper limit of normal
- Creatinine no greater than 1.5 mg/dL OR creatinine clearance at least 60 mL/min
- No uncompensated coronary artery disease on electrocardiogram or physical examination
- No history of myocardial infarction or severe/unstable angina within the past 6 months
- No severe peripheral vascular disease associated with diabetes mellitus
- No deep vein or arterial thrombosis within the past 3 months
- No pulmonary embolism within the past 3 months
- No significant uncontrolled underlying medical or psychiatric illness
- No serious active infection
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No active second malignancy except nonmelanomatous skin cancer or carcinoma in situ of
the cervix
- Patients are not considered to have active malignancy if they have completed therapy
and are considered to be at less than 30% risk of relapse
- No history of severe allergic or anaphylactic reactions to paclitaxel or docetaxel
PRIOR CONCURRENT THERAPY:
- No more than 1 prior systemic chemotherapy regimen
- At least 4 weeks since prior systemic chemotherapy and recovered
- Prior intrapleural cytotoxic agents (including bleomycin) allowed
- No concurrent chemotherapy
- At least 4 weeks since prior radiotherapy and recovered
- No concurrent radiotherapy
- At least 30 days since prior investigational drug and recovered
- No concurrent investigational drug
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Hedy L. Kindler, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00006014
Organization ID
NCI-2012-02351
Secondary IDs
UCCRC-10409
Responsible Party
Sponsor
Study Sponsor
National Cancer Institute (NCI)
Study Sponsor
Hedy L. Kindler, MD, Study Chair, University of Chicago
Verification Date
February 2009