Brief Title
Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer
Official Title
Radiofrequency Ablation of Pulmonary Malignancy
Brief Summary
RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. CT-guided radiofrequency ablation may be effective treatment for lung cancer. PURPOSE: Phase II trial to study the effectiveness of radiofrequency ablation in treating patients who have refractory or advanced lung cancer.
Detailed Description
OBJECTIVES: - Determine the safety and toxicity of radiofrequency ablation in patients with refractory or advanced pulmonary malignancies. - Determine the efficacy of this treatment, in terms of local control, in these patients. - Determine whether CT scan is a reasonable imaging assessment tool for treatment delivery and follow-up in these patients. OUTLINE: Patients undergo percutaneous CT-guided radiofrequency ablation directly to the tumor over 2 hours. Patients are followed at 1, 3, 6, and 12 months. PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
Study Phase
Phase 2
Study Type
Interventional
Condition
Lung Cancer
Intervention
radiofrequency ablation
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Procedure
Estimated Enrollment
30
Start Date
May 2000
Primary Completion Date
December 2006
Eligibility Criteria
Inclusion Criteria: - Diagnosis of a primary or secondary intrathoracic malignancy - Any cell type or origin - Involving the intrapulmonary, mediastinal, or pleural/chest wall - Inoperable primary or metastatic cancer to the lung - Refractory to or not amenable to conventional therapy (e.g., surgery, chemotherapy, or radiotherapy) - Single or multiple lesions that are non-contiguous with vital structures or organs such as: - Trachea - Heart - Aorta - Great vessels - Esophagus - Less than 5 cm in largest dimension - Accessible via percutaneous transthoracic route - Hepatic: - Coagulation profile normal
Gender
All
Ages
N/A - N/A
Accepts Healthy Volunteers
No
Contacts
Robert D. Suh, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00024076
Organization ID
CDR0000068889
Secondary IDs
UCLA-9908024
Responsible Party
Sponsor
Study Sponsor
Jonsson Comprehensive Cancer Center
Study Sponsor
Robert D. Suh, MD, Study Chair, Jonsson Comprehensive Cancer Center
Verification Date
July 2012