Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate

Related Clinical Trial
PF-06952229 Treatment in Adult Patients With Advanced Solid Tumors Mesothelin-targeted CAR T-cell Therapy in Patients With Mesothelioma Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma Olaparib in Patients With HRD Malignant Mesothelioma αPD1-MSLN-CAR T Cells for the Treatment of MSLN-positive Advanced Solid Tumors Intravenous Magnesium in Patients Receiving Cisplatin SAKK 17/18 (ORIGIN) MPM & NSCLC >1st Line Gemci & Atezo Ph II Transitions Project High Resolution Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome Cryoablation for the Promotion of Local Tumor Infiltration in Patients With Mesothelioma Study of Recombinant Human Anti-PD-1 Monoclonal Antibody in Patients With Advanced Tumours Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumors Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for the Treatment of Resectable, Refractory, or Recurrent Abdominal or Pelvic Tumors in Pediatric Patients, T.O.A.S.T. I.T. Study 18F-FSPG PET/CT for Cancer Patients on Therapy Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be Removed by Surgery and Liver or Kidney Dysfunction Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso Molecular Analysis of Thoracic Malignancies A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously Treated Advanced Solid Tumor Patients Early Palliative Care in Advanced Lung and Gastrointestinal Malignancies Oral TrkA Inhibitor VMD-928 for Treatment of Advanced Adult Solid Tumors or Lymphoma Cryotherapy in Treating Patients With Lung Cancer That Has Spread to the Other Lung or Parts of the Body Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer Printed Education Materials in Patients Who Are Finishing Treatment for Stage I, Stage II, or Stage IIIA Breast Cancer, Colorectal Cancer, Prostate Cancer, or Chest Cancer Surgery Plus Intraoperative Peritoneal Hyperthermic Chemotherapy (IPHC) to Treat Peritoneal Carcinomatosis Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion Pulmonary Interstitial Lymphography in Early Stage Lung Cancer Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors 177Lu-DOTA-TATE and Olaparib in Somatostatin Receptor Positive Tumours EF5 in Detecting Oxygen Level and Blood Vessels in Tumor Cells of Patients Undergoing Photodynamic Therapy for Intraperitoneal or Pleural Cancer Phase 1/2 Trial of TC-210 T Cells in Patients With Advanced Mesothelin-Expressing Cancer Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer Amatuximab for High Mesothelin Cancers αDC1 Vaccine + Chemokine Modulatory Regimen (CKM) as Adjuvant Treatment of Peritoneal Surface Malignancies First-in-human Study of S-588210 (S-488210+S-488211) Study of the Glutaminase Inhibitor CB-839 in Solid Tumors Depsipeptide/Flavopiridol Infusion for Cancers of the Lungs, Esophagus, Pleura, Thymus or Mediastinum CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer Rapid Autopsy and Procurement of Cancer Tissue Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining Inhaled Doxorubicin in Treating Patients With Advanced Solid Tumors Affecting the Lungs Mithramycin for Lung, Esophagus, and Other Chest Cancers APG-2449 in Patients With Advanced Solid Tumors CryoSpray Ablation(tm)in Malignant Airway Disease to Determine Safety, and Tissue Effect in the Lung (ICE the MAD) Clinical Trial of Intraperitoneal Hyperthermic Chemotherapy Study of Safety and Tolerability of Intravenous CRS-207 in Adults With Selected Advanced Solid Tumors Who Have Failed or Who Are Not Candidates for Standard Treatment Feasibility of an Early Palliative Care Intervention for Metastatic Cancer Patients. A Phase 2 Study. Rehabilitation by Effort for Patients With Advanced Bronchial Cancer A Study of LY3023414 in Participants With Advanced Cancer Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas Study of FAK (Defactinib) and PD-1 (Pembrolizumab) Inhibition in Advanced Solid Malignancies (FAK-PD1) A Single-Dose Pilot Study of Radiolabeled Amatuximab (MORAb-009) in Mesothelin Over Expressing Cancers A Study of MORAb-009 in Subjects With Pancreatic Cancer, Mesothelioma, or Certain Types of Ovarian or Lung Cancer Comparison of Progel Sealant to Standard of Care (SOC) for Patients Undergoing Decortication Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin Study of the Combination of Tivantinib Plus Pemetrexed and Carboplatin Influence of Psychosocial Distress and Lifetime Trauma Exposure on Traumatic Stress Among Oncology Patients on Clinical Trials Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, Non-Small Cell Lung Cancer, or Mesothelioma Study of Pemetrexed in Mesothelioma and Lung Cancer Patients With Fluid Around the Lungs or Abdomen Dose Individualization of Pemetrexed – IMPROVE-III Dose Individualization of Pemetrexed – IMPROVE-II Dose Individualization of Pemetrexed – IMPROVE-I Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Malignant Mesothelioma Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Peritoneal Cancer Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide Decitabine in Treating Patients With Unresectable Lung or Esophageal Cancer or Malignant Mesothelioma of the Pleura Radical Pleurectomy/Decortication (PD) and Intensity Modulated Radiotherapy (IMRT) uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer, Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung Cediranib Maleate in Treating Patients With Malignant Mesothelioma That Cannot Be Removed By Surgery Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma. Gefitinib in Treating Patients With Malignant Mesothelioma DENdritic Cell Immunotherapy for Mesothelioma Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma A Single Dose FMT Infusion as an Adjunct to Keytruda for Metastatic Mesothelioma High-Dose Megestrol in Treating Patients With Metastatic Breast Cancer, Endometrial Cancer, or Mesothelioma Extrapleural Pneumonectomy With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Amifostine and Sodium Thiosulfate Tivantinib in Treating Patients With Previously Treated Malignant Mesothelioma Vaccine Therapy in Treating Patients With Stage I, Stage II, or Stage IIIA Non-small Cell Lung Cancer or With Stage I or Stage II Mesothelioma ALIMTA (Pemetrexed) Alone or in Combination With Cisplatin for Patients With Malignant Mesothelioma. Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901) Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery Phase II Study of Valproate and Doxorubicin in Malignant Mesothelioma Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers Radiation Therapy in Preventing Metastatic Cancer in Patients Who Have Diagnostic Procedures to Identify Malignant Mesothelioma SPECTAlung: Screening Patients With Thoracic Tumors for Efficient Clinical Trial Access Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma Sorafenib in Previously Treated Malignant Mesothelioma A Phase II Study of the Association of Glivec® Plus Gemzar® in Patients With Unresectable, Refractory, Malignant Mesothelioma Mesothelin and Osteopontin as Diagnostic Markers in Patients With Mesothelioma or Atypical Mesothelial Hyperplasia Erlotinib Hydrochloride in Treating Patients With Malignant Peritoneal Mesothelioma A Study of VEGF-Antisense Oligonucleotide in Combination With Pemetrexed and Cisplatin for the Treatment of Advanced Malignant Mesothelioma Biomarkers of Angiogenesis and Disease in Patients With Unresectable Malignant Mesothelioma Treated on Clinical Trial CALGB-30107 Capecitabine in Treating Patients With Malignant Mesothelioma A Pilot Study to Explore the Role of Gut Flora in Metastatic Mesothelioma Olaparib in People With Malignant Mesothelioma CheckpOiNt Blockade For Inhibition of Relapsed Mesothelioma IP3R Modulation by Cancer Genes in Mesothelioma Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant Mesothelioma PXD101 as Second-Line Therapy in Treating Patients With Malignant Mesothelioma of the Chest That Cannot Be Removed By Surgery Combination Chemotherapy Before Surgery in Treating Patients With Mesothelioma of the Lung Cisplatin With Alimta or Gemcitabine in Long Infusion for Mesothelioma Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma A Double Blind, Placebo Controlled, Randomized Phase II Study Evaluating Gemcitabine With or Without Ramucirumab , for II Line Treatment MPM Biomarkers to Detect Mesothelioma Early in Patients Exposed to Asbestos or Vermiculite Raltitrexed in Treating Patients With Malignant Mesothelioma That Cannot Be Surgically Removed Dendritic Cell-based Immunotherapy Combined With Low-dose Cyclophosphamide in Patients With Malignant Mesothelioma Gemcitabine and Epirubicin in Treating Patients With Malignant Mesothelioma Ph 2/3 Study in Subjects With MPM to Assess ADI-PEG 20 With Pemetrexed and Cisplatin Erlotinib in Treating Patients With Malignant Mesothelioma of the Lung Mesothelin-Targeted Immunotoxin LMB-100 in Combination With SEL-110 in Subjects With Malignant Pleural or Peritoneal Mesothelioma ONCONASE Plus Doxorubicin Versus Doxorubicin Alone For Patients With Malignant Pleural or Peritoneal Mesothelioma Who Have Had No More Than One Prior Chemotherapy Regimen Safety and Efficacy of Oshadi D and Oshadi R for Malignant Mesothelioma Treatment SU5416 in Treating Patients With Malignant Mesothelioma Palliative Therapy With or Without Chemotherapy in Treating Patients With Malignant Mesothelioma Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma Autologous Redirected RNA Meso-CIR T Cells Velcade and Eloxatin for Patients With Malignant Pleural or Peritoneal Mesothelioma Antineoplaston Therapy in Treating Patients With Advanced Mesothelioma Screening of Alberta Asbestos Exposed Workers for Lung Cancer and Mesothelioma Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma Cisplatin, Pemetrexed and Bevacizumab for Untreated Malignant Mesothelioma Mesothelioma Avastin Plus Pemetrexed-cisplatin Study Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma MesomiR 1: A Phase I Study of TargomiRs as 2nd or 3rd Line Treatment for Patients With Recurrent MPM and NSCLC Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery Metronomic Chemotherapy Based on Adaptative Bio-mathematical Model of Oral Vinorelbine in Patients With NSCLC or MPM Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes Pleurectomy/ Decortication (P/D) Preceded or Followed by Chemotherapy in Patients With Early Stage MPM Cisplatin, Pemetrexed, and Imatinib Mesylate in Malignant Mesothelioma An Open-label, Phase II Trial of ZD1839 (IRESSA) in Patients With Malignant Mesothelioma Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma Tomotherapy Treatment for Mesothelioma Bevacizumab (Avastin) and Erlotinib (Tarceva) in Previously Treated Mesothelioma Eloxatin® Plus Gemcitabine Chemotherapy for Mesothelioma Mesothelioma and Radical Surgery 2 Pemetrexed, Cisplatin, and Vitamin B12 in Treating Patients With Mesothelioma of the Chest That Cannot Be Removed by Surgery Isolated Thoracic Perfusion (ITP-F) for MPM Dendritic Cells Loaded With Allogeneous Cell Lysate in Mesothelioma Patients An Efficacy Study of Milataxel (TL139) Administered Orally for Malignant Mesothelioma S9810: Gemcitabine Plus Cisplatin in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot Be Removed by Surgery Tumor Cell Vaccines With ISCOMATRIX Adjuvant and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers and Malignant Pleural Mesotheliomas Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma The Anti-CTLA-4 Monoclonal Antibody Tremelimumab in Malignant Mesothelioma Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos Pemetrexed Plus Gemcitabine as Front-Line Chemotherapy for Patients With Malignant Pleural or Peritoneal Mesothelioma Serum Biomarkers in Diagnosis of Mesothelioma Short Neoadjuvant Hemithoracic IMRT for MPM Vaccine Therapy and Ganciclovir in Treating Patients With Mesothelioma Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma A Clinical Study With Tremelimumab as Monotherapy in Malignant Mesothelioma Standard Chemotherapy With of Without Axitinib in Malignant Mesothelioma Nivolumab in Patients With Recurrent Malignant Mesothelioma Study of Pemetrexed Plus Cisplatin in Patients With Malignant Pleural Mesothelioma Four Versus Six Cycles of Pemetrexed/Platinum for MPM A Study Comparing Pemetrexed Plus Best Supportive Care Versus Best Supportive Care Alone in the Treatment of Mesothelioma Nintedanib (BIBF 1120) in Mesothelioma Surgery for Mesothelioma After Radiation Therapy “SMART” for Resectable Malignant Pleural Mesothelioma Ecteinascidin 743 in Treating Patients With Malignant Mesothelioma Phase II Study of NGR-hTNF Versus Placebo as Maintenance Treatment in Patients With Advanced MPM Liposomal-Cisplatin Analogue (L-NDDP) in Treating Patients With Malignant Pleural Mesothelioma AMG 102, Pemetrexed Disodium, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma Study of Nivolumab Combined With Ipilimumab Versus Pemetrexed and Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma Patients Intrapleural Measles Virus Therapy in Patients With Malignant Pleural Mesothelioma Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas A Phase II Trial to Assess TroVax® Plus Chemotherapy in Patients With Malignant Pleural Mesothelioma Vinorelbine in Mesothelioma Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma Cisplatin, Interferon Alfa, Surgery, and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma S0509 – AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery Sunitinib in Treating Patients With Advanced Malignant Pleural Mesothelioma Staging Procedures to Diagnose Malignant Pleural Mesothelioma Observational Prospective Analysis of Biological Characteristics of Mesothelioma Patients Phase II MEDI4736 in Combination With Chemotherapy for First-Line Treatment of Unresectable Mesothelioma PIT: Prophylactic Irradiation of Tracts in Patients With Malignant Pleural Mesothelioma S0722: Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients Pemetrexed Plus Gemcitabine or Carboplatin for Patients With Advanced Malignant Pleural Mesothelioma Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma Pemetrexed (ALIMTA) Plus Cisplatin Followed by Surgery and Radiation Therapy for Mesothelioma Pazopanib in Treating Patients With Malignant Pleural Mesothelioma Intrapleural Gene Transfer for Pleural Mesothelioma Phase II Study of Bevacizumab, Pemetrexed and Carboplatin as First-Line Therapy in Malignant Pleural Mesothelioma Thromboelastography During Surgery for Malignant Pleural Mesothelioma Evaluation of CRS-207 With Pembrolizumab in Previously Treated Malignant Pleural Mesothelioma (MPM) Ipilimumab and Nivolumab in the Treatment of Malignant Pleural Mesothelioma Carboplatin, Bevacizumab and Pemetrexed in the First-Line Treatment of Patients With Malignant Pleural Mesothelioma (MPM) An Efficacy Study of MORAb-009 (Amatuximab) in Subjects With Pleural Mesothelioma A Study of Pembrolizumab in Combination With Cisplatin and Pemetrexed in Advanced Malignant Pleural Mesothelioma (MPM) (MK-3475-A17) Pemetrexed Disodium and Cisplatin Followed by Surgery With or Without Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma Pharmacogenetics Of Vinorelbine In Malignant Pleural Mesothelioma Patients Pemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy Psychosocial Needs and Exploration of Online Support for Patients With Mesothelioma Combination Gene Transfer and Chemotherapy Cisplatin With or Without Pemetrexed Disodium in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot be Removed by Surgery Molecular Predictors of Pemetrexed and Carboplatin Response in Malignant Pleural Mesothelioma (MPM) Patients Cisplatin With or Without Raltitrexed in Treating Patients With Malignant Mesothelioma of the Pleura Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma Bortezomib in Treating Patients With Malignant Pleural Mesothelioma Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM) A Phase Ib Trial of a Maintenance Multipeptide Vaccine (S-588210) in Patients With Unresectable Malignant Pleural Mesothelioma Without Progression After First-Line Chemotherapy DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma Nintedanib as Switch Maintenance Treatment of Pleural Malignant Mesothelioma A Phase II Study of Single-agent DOVitinib in Advanced Malignant PlEural Mesothelioma Which Has Progressed Following Prior Platinum-Antifolate Chemotherapy Combination Chemotherapy With or Without Surgery and Chemoradiotherapy in Treating Patients With Malignant Pleural Mesothelioma The IMmunotherapy Pleural 5-ALA PDT Intrapleural Cryotherapy for Malignant Pleural Mesothelioma Pemetrexed Disodium and Cisplatin Followed By Surgery and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma A Study of BBI608 in Combination With Pemetrexed and Cisplatin in Adult Patients With Malignant Pleural Mesothelioma MesoTRAP: A Study Comparing Video-assisted Thoracoscopic Partial Pleurectomy/Decortication With Indwelling Pleural Catheter in Patients With Trapped Lung Due to Malignant Pleural Mesothelioma. Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma Pembrolizumab and Hypofractionated Stereotactic Radiotherapy in Patients With Malignant Pleural Mesothelioma Study of CBP501 + Pemetrexed + Cisplatin on MPM (Phase I/II) NGR015: Study in Second Line for Patient With Advanced Malignant Pleural Mesothelioma Pretreated With Pemetrexed Dendritic Cell-based Immunotherapy in Mesothelioma MTG201 Plus Nivolumab in Patients With Relapsed Pleural Mesothelioma Nintedanib in Treating Patients With Malignant Pleural Mesothelioma That Is Recurrent Active Symptom Control With or Without Chemotherapy in Treating Patients With Malignant Pleural Mesothelioma Do Your Genes Put You at a Higher Risk of Developing Mesothelioma Trimodality Therapy for Malignant Pleural Mesothelioma Pleurectomy/Decortication Followed by Intrathoracic/Intraperitoneal Heated Cisplatin for Malignant Pleural Mesothelioma Intracavitary Cisplatin-Fibrin Localized Chemotherapy After P/D or EPP for Malignant Pleural Mesothelioma Ganetespib With Platinum, in Patients With Malignant Pleural Mesothelioma Efficacy & Safety of rAd-IFN Administered With Celecoxib & Gemcitabine in Patients With Malignant Pleural Mesothelioma A Phase 2 Study of Durvalumab in Combination With Tremelimumab in Malignant Pleural Mesothelioma Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers Phase II Study of Six Hours Low Dose Gemcitabine Plus Cisplatin in the Treatment for Advanced Pleural Mesothelioma Safety and Efficacy of Listeria in Combination With Chemotherapy as Front-line Treatment for Malignant Pleural Mesothelioma Intrapleural Photodynamic Therapy in a Multimodal Treatment for Patients With Malignant Pleural Mesothelioma Re-directed T Cells for the Treatment (FAP)-Positive Malignant Pleural Mesothelioma Concurrent Pemetrexed/Cisplatin With Pleural Intensity Modulated Radiation Therapy for Patients With Unresectable Malignant Pleural Mesothelioma Study of Cytoreductive Surgery and Hyperthermic Intraoperative Chemotherapy With Pemetrexed and Cisplatin for Malignant Pleural Mesotheliomas Effect of FAS and FAS Ligand Polymorphisms on Patients With Platinum-Based -Treated Malignant Pleural Mesothelioma Dasatinib in Resectable Malignant Pleural Mesothelioma Palliative Treatment With Liposomal Doxorubicin Plus Cisplatin for Patients With Malignant Pleural Mesothelioma Effect of Expression of CD74 and VEGF on Outcome of Treatment in Patients With Malignant Pleural Mesothelioma Clinical Study of YS110 in Patients With Malignant Pleural Mesothelioma Lurbinectedin Monotherapy in Patients With Progressive Malignant Pleural Mesothelioma. Safety and Efficacy of TTFields (150 kHz) Concomitant With Pemetrexed and Cisplatin or Carboplatin in Malignant Pleural Mesothelioma (STELLAR) A Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma Direct Injection of Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma A Phase I/II Study of First Line Vorinostat With Pemetrexed-cisplatin, in Patients With Malignant Pleural Mesothelioma ATREUS – Phase II Study on the Activity of Trabectedin in Patients With Malignant Pleural Mesothelioma (MPM) Accelerated Hypofractionated Radiotherapy in the Treatment of Malignant Pleural Mesothelioma Pembrolizumab + Defactinib In Pleural Mesothelioma Window of Opportunity Study of VS-6063 (Defactinib) in Surgical Resectable Malignant Pleural Mesothelioma Participants A Study of Atezolizumab in Unresectable or Advaced Malignant Pleural Mesothelioma A Clinical Trial of ADI-PEG 20TM in Patients With Malignant Pleural Mesothelioma Study of NGR-hTNF as Single Agent in Patients Affected by Advanced or Metastatic Malignant Pleural Mesothelioma Extrapleural Pneumonectomy /Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural Mesothelioma Transarterial Chemoperfusion: Cisplatin, Methotrexate, Gemcitabine for Unresectable Pleural Mesothelioma Study of Carboplatin and Vinorelbine in Malignant Pleural Mesothelioma Vascularity Impact on the Treatment Outcome in Malignant Pleural Mesothelioma(VITMPM) Safety Confirmation Study of Pemetrexed Plus Cisplatin in Patients With Malignant Pleural Mesothelioma Intrapleural Administration of HSV1716 to Treat Patients With Malignant Pleural Mesothelioma. Placebo Controlled Study of VS-6063 in Subjects With Malignant Pleural Mesothelioma Response Evaluation in Malignant Pleural Mesothelioma Gemcitabine in Long Infusion and Cisplatin for Malignant Pleural Mesothelioma Treatment

Brief Title

Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate

Official Title

A Phase II Feasibility Study of Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate Followed ny Adjuvant ALIMTA/Cisplatin

Brief Summary

      The purposes of this study are: to determine the feasibility of administering adjuvant
      cisplatin plus ALIMTA to patients who undergo surgery with heated cisplatin during surgery;
      to determine the effects (good and bad) of this combined modality approach in patients with
      mesothelioma; to evaluate cisplatin effects by determining where it goes and how it is
      excreted in the body from the collection of tissues and cisplatin samples; to collect and
      analyze discarded samples of mesothelioma tumor during surgery to help determine the genetic
      make-up of the disease.
    

Detailed Description

      OBJECTIVES:

      Primary

        -  To determine the feasibility of administering adjuvant cisplatin plus Alimta to patients
           undergoing surgery with hyperthermic cisplatin.

      Secondary

        -  To determine the morbidity and mortality of this treatment protocol

        -  To determine time to tumor recurrence and patient survival

        -  To evaluate the pharmacokinetics of intraoperatively administered cisplatin

      DETAILS:

        -  Patients will undergo surgery, which is part of the standard care for mesothelioma, by a
           procedure called pleurectomy/decortication. This involves removal of the lining of the
           lung and all visible disease. Resection of the lining of the heart and the muscle that
           separates the chest and abdomen is occasionally necessary.

        -  Mesothelioma samples will be taken during the surgery. These samples will be used in a
           laboratory study to better understand the genetic makeup of the mesothelioma and to
           improve our ability to diagnose this disease.

        -  After the conclusion of the surgery, if a patient has less than 1cm thickness of
           residual gross disease in one or more areas, then the patient will continue on this
           study. If more than this volume of tumor is present, then the patient will receive
           additional treatment off-study.

        -  Heated chemotherapy (cisplatin) will be given in the operating room immediately
           following surgery. This treatment consists of a one-hour lavage of the chest and
           abdominal cavity with heated cisplatin through the surgical incision. At the completion
           of the hour, sodium thiosulfate is given intravenously for 6 hours to reduce potential
           side effects.

        -  During the surgery and for four hours following the completion of the cisplatin lavage,
           blood samples, urine samples, chest wall muscle samples, and samples of the chemotherapy
           solution will be taken in order to measure the concentration of chemotherapy and the
           impact of cisplatin in these samples.

        -  Patients will remain in the hospital until they have recovered from surgery (7-14 days).
           In addition to standard post-operative care, blood tests will be done on a daily basis.
           Following discharge from the hospital, patients will be seen 1-2 weeks post-operatively
           for additional blood work. An echocardiogram will be done 6 weeks and 6 months
           post-operatively to assess heart function.

        -  Chemotherapy treatment consists of ALIMTA plus cisplatin on Day 1 of every 21-day
           chemotherapy cycle. A total of 3 cycles will be given starting 6-10 weeks after surgery.

        -  Folic acid, vitamin B12 and dexamethasone will be given in addition to the chemotherapy
           to help reduce side effects of the chemotherapy drugs.

        -  Approximately 30 days after the last dose of ALIMTA plus cisplatin, a CT scan(s) and
           blood work will be performed. In addition, patients will get a CT scan(s) every 3 months
           for approximately 24 months from the completion of study treatment.

        -  Long term follow-up will consist of clinic visits every 3 months for 2 years, every 6
           months for 2 years, and then once a year.
    

Study Phase

Phase 2

Study Type

Interventional


Primary Outcome

Adjuvant Chemotherapy Completion Rate


Condition

Pleural Mesothelioma

Intervention

Cisplatin

Study Arms / Comparison Groups

 Surgery+Heated Cisplatin+Sodium Thiosulfate+Adjuvant CT
Description:  Participants undergo surgery, Pleurectomy/Decortication, followed by heated cisplatin given as a one-hour lavage of the chest and abdominal cavity then sodium thiosulfate given intravenously over 6 hours. The adjuvant chemotherapy regimen beginning 6-10 weeks after surgery is a combination of cisplatin and Alimta each given day 1 of a 21-day cycle for 3 cycles.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

16

Start Date

April 2004

Completion Date

July 2010

Primary Completion Date

July 2010

Eligibility Criteria

        Inclusion Criteria:

          -  Histopathologic confirmation of malignant pleural mesothelioma

          -  Patients who are able to tolerate surgical cytoreduction but unable to undergo
             extrapleural pneumonectomy due to poor cardiopulmonary reserve or tumor invasion or
             those with minimal disease

          -  Male on non-pregnant female

          -  18 years of age or older

          -  No evidence of spread outside the ipsilateral hemithorax by chest CT and chest MRI

          -  Ejection fraction > 45%

          -  Pre-operative WBC > 4K/uL

          -  Estimated life expectancy of at least 12 weeks

          -  Evidence of adequate renal and hepatic function

          -  Grossly normal contralateral pulmonary function with a chest radiograph and chest CT
             scan

          -  Karnofsky performance status of 70% or greater

          -  No evidence of disease progression by chest CT or chest MRI, obtained at 8 weeks
             following surgery

        Exclusion Criteria:

          -  Extended disease outside the ipsilateral hemithorax as determined on pre-operative
             radiographs or intraoperative findings

          -  Positive extrapleural nodes as determined by mediastinoscopy

          -  Gross disease (estimated thickness > 10mm at any intrathoracic location) present
             within the hemithorax after surgery

          -  Evidence of distant metastatic disease

          -  Severe non-malignant co-morbid disease, uncontrolled angina, myocardial infarction on
             the past 6 months, renal insufficiency, liver disease, pulmonary hypertension

          -  Pregnant or breast-feeding

          -  Serious concomitant systemic disorders

          -  Presence of active concomitant malignancy

          -  Psychiatric or addictive disorders, which would preclude informed consent

          -  Previous chemotherapy or radiation therapy for mesothelioma

          -  Chemotherapy or radiation therapy administered within 3 years for another malignancy
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

David J. Sugarbaker, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00165503

Organization ID

04-063


Responsible Party

Principal Investigator

Study Sponsor

Dana-Farber Cancer Institute

Collaborators

 Brigham and Women's Hospital

Study Sponsor

David J. Sugarbaker, MD, Principal Investigator, Brigham and Women's Hospital


Verification Date

July 2016