Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors

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Brief Title

Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors

Official Title

DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood

Brief Summary

      RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
      help doctors identify biomarkers related to cancer.

      PURPOSE: This research trial is studying genes in tumor samples from younger patients with
      ovarian or testicular sex cord stromal tumors.
    

Detailed Description

      OBJECTIVES:

        -  To assess the role of DICER1 mutations and miRNA pathways in the etiology and
           progression of ovarian or testicular sex cord stromal tumors.

      OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression
      by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector.
      Results are then correlated with medical data, including age at diagnosis, diagnosis,
      pathology report, presenting symptoms, family history, treatment, outcome, and length of
      follow-up, when available.
    


Study Type

Observational


Primary Outcome

Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis


Condition

Childhood Germ Cell Tumor

Intervention

RNA analysis


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Genetic

Estimated Enrollment

50

Start Date

April 2012


Primary Completion Date

July 2016

Eligibility Criteria

        DISEASE CHARACTERISTICS:

          -  Fixed and frozen tissue samples from the ATBR01 B1 tissue bank and from the
             International Pleuropulmonary Blastoma Registry, Children's Hospital of Boston, and
             Massachusetts General Hospital

          -  Tissue samples from patients diagnosed with:

               -  Ovarian

                    -  Sertoli-Leydig cell tumor

                    -  Juvenile granulosa cell tumor

                    -  Adult granulosa cell tumor

                    -  Gynandroblastoma

                    -  Sex cord stromal tumor with annular tubules

                    -  Sex cord stromal tumor, undifferentiated

                    -  Sertoli tumor

                    -  Leydig tumor

               -  Testicular:

                    -  Granulosa cell tumor

                    -  Sertoli tumor

                    -  Leydig tumor

                    -  Sertoli-Leydig

                    -  Undifferentiated stromal tumor

        PATIENT CHARACTERISTICS:

          -  Not specified

        PRIOR CONCURRENT THERAPY:

          -  Not specified
      

Gender

All

Ages

N/A - 120 Years

Accepts Healthy Volunteers

No

Contacts

Dana A. Hill, MD, , 



Administrative Informations


NCT ID

NCT01572467

Organization ID

ARAR12B2

Secondary IDs

COG-ARAR12B2

Responsible Party

Sponsor

Study Sponsor

Children's Oncology Group

Collaborators

 National Cancer Institute (NCI)

Study Sponsor

Dana A. Hill, MD, Principal Investigator, Children's National Research Institute


Verification Date

July 2016