Brief Title
Reading Disability in Children With NF1
Official Title
Neuropsychological Characterisation of Cognitive Deficits Involved in Reading Disability in Children With NF1
Brief Summary
A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.
Detailed Description
To determine the phonological and visio -spatial performances at the NF1 children.
Study Type
Interventional
Primary Outcome
Phonological deficits evaluated by the metaphonological capabilities including a subtraction test and phonemic Acronym test and memory capacity with phonological phonological memory test.
Secondary Outcome
Visual-perceptual performance established from three tests: Test of Identical Forms (Thurstone), Judgment Test of orientation Lines (Benton) and global and partial deferral Tasks (S Valdois).
Condition
Neurofibromatosis Type 1
Intervention
Neuropsychological assessments
Study Arms / Comparison Groups
Children NF1
Description: Children diagnosed with NF1 according the NIH criteria Neuropsychological assessments
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
181
Start Date
June 2009
Completion Date
April 2014
Primary Completion Date
April 2014
Eligibility Criteria
Inclusion Criteria: - Age included between 8 and 12 years - Child presenting a type 1 neurofibromatosis according to 2 criteria in the following criteria list : - At least 6 café au lait spots - 2 or more neurofibromas or 1 plexiform neurofibroma - axillary or inguinal freckling - 1 optic nerf glioma - 2 or more Lisch nodules - 1 osseous lesion as sphenoid dysplasia or thinning of the long bone cortex with or without pseudoarthrosis - 1 A first degree relative (parent, sibling, or offspring) with NF1 by the above criteria - Membership in a national insurance - Consent of the child and the parents Exclusion Criteria: - Mental retardation (QI T < 70) - Treated or untreated epilepsy - Visual deficit (visual Acuteness < 4/10 - Presence of a symptomatic optic glioma - Presence of a brain tumor.
Gender
All
Ages
8 Years - 12 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Yves CHAIX, Professor, ,
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT02397967
Organization ID
08 113 01
Responsible Party
Sponsor
Study Sponsor
University Hospital, Toulouse
Study Sponsor
Yves CHAIX, Professor, Principal Investigator,
Verification Date
March 2015