Reading Disability in Children With NF1

Brief Title

Reading Disability in Children With NF1

Official Title

Neuropsychological Characterisation of Cognitive Deficits Involved in Reading Disability in Children With NF1

Brief Summary

      A national, multicenter, randomized, transverse clinical trial, estimating the existence of
      phonological deficits in children with NF1 children compared with control children without
      NF1 with the same reading level.
    

Detailed Description

      To determine the phonological and visio -spatial performances at the NF1 children.
    

Study Type

Interventional

Primary Outcome

Phonological deficits evaluated by the metaphonological capabilities including a subtraction test and phonemic Acronym test and memory capacity with phonological phonological memory test.

Secondary Outcome

 Visual-perceptual performance established from three tests: Test of Identical Forms (Thurstone), Judgment Test of orientation Lines (Benton) and global and partial deferral Tasks (S Valdois).

Condition

Neurofibromatosis Type 1

Intervention

Neuropsychological assessments

Study Arms / Comparison Groups

 Children NF1

Description:  Children diagnosed with NF1 according the NIH criteria Neuropsychological assessments

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Status

Other

Estimated Enrollment

181

Start Date

June 2009

Completion Date

April 2014

Primary Completion Date

April 2014

Eligibility Criteria

        Inclusion Criteria:

          -  Age included between 8 and 12 years

          -  Child presenting a type 1 neurofibromatosis according to 2 criteria in the following
             criteria list :

               -  At least 6 café au lait spots

               -  2 or more neurofibromas or 1 plexiform neurofibroma

               -  axillary or inguinal freckling

               -  1 optic nerf glioma

               -  2 or more Lisch nodules

               -  1 osseous lesion as sphenoid dysplasia or thinning of the long bone cortex with
                  or without pseudoarthrosis

               -  1 A first degree relative (parent, sibling, or offspring) with NF1 by the above
                  criteria

          -  Membership in a national insurance

          -  Consent of the child and the parents

        Exclusion Criteria:

          -  Mental retardation (QI T < 70)

          -  Treated or untreated epilepsy

          -  Visual deficit (visual Acuteness < 4/10

          -  Presence of a symptomatic optic glioma

          -  Presence of a brain tumor.
      

Gender

All

Ages

8 Years - 12 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Yves CHAIX, Professor, , 

Location Countries

France

Location Countries

France

NCT ID

NCT02397967

Organization ID

08 113 01

Responsible Party

Sponsor

Study Sponsor

University Hospital, Toulouse

Study Sponsor

Yves CHAIX, Professor, Principal Investigator, 

Verification Date

March 2015