Brief Title
Photoacoustic Imaging in Detecting Ovarian or Fallopian Tube Cancer
Official Title
Transvaginal Ultrasound and Photoacoustic Imaging of the Ovaries and the Fallopian Tubes: A Clinical Feasibility Study
Brief Summary
This pilot clinical trial studies how well photoacoustic imaging works in detecting ovarian or fallopian tube cancer. Photoacoustic imaging is an imaging method that uses lasers to light up tissue, and then converts the light information into ultrasound images. Photoacoustic imaging can provide images of the structure of tissues, as well as their function and the levels of molecules, such as the flow of blood in blood vessels and the level of oxygen in the blood. Photoacoustic imaging may help doctors determine whether a mass is benign (non-cancerous) or cancerous based on the molecular differences between cancer and normal tissue. It may be more accurate and less expensive than other imaging methods, and does not expose patients to radiation.
Detailed Description
PRIMARY OBJECTIVES: I. To assess the performance of photoacoustic imaging (PAI) in detection of ovarian cancer in a clinical setting and to help improve the design of the next generation hand held PAI probe. SECONDARY OBJECTIVES: I. To evaluate vasculature and oxygen saturation in lesions based on PAI-measurements. OUTLINE: Patients undergo PAI over 15-30 minutes prior to the ovarian excision.
Study Type
Interventional
Primary Outcome
Depth of lesion from skin surface as measured by ultrasound (US)
Condition
Fallopian Tube Carcinoma
Intervention
Photoacoustic Imaging
Study Arms / Comparison Groups
Diagnostic (PAI)
Description: Patients undergo PAI over 15-30 minutes prior to the ovarian excision.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Procedure
Estimated Enrollment
0
Start Date
September 2016
Completion Date
November 2018
Primary Completion Date
September 2017
Eligibility Criteria
Inclusion Criteria: - Patients must be undergoing ovarian resection - Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: - Patients who have had primary surgical excision - Pregnant or lactating women
Gender
Female
Ages
18 Years - 80 Years
Accepts Healthy Volunteers
No
Contacts
Sanjiv Gambhir, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT02530606
Organization ID
GYNOPF0014
Secondary IDs
NCI-2015-01284
Responsible Party
Sponsor
Study Sponsor
Stanford University
Study Sponsor
Sanjiv Gambhir, Principal Investigator, Stanford Cancer Institute
Verification Date
November 2018