Brief Title
Phase 2 Study of Pembrolizumab, DPX-Survivac Vaccine and Cyclophosphamide in Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer
Official Title
A Phase 2 Study of Pembrolizumab (MK-3475), DPX-Survivac Vaccine and Low Dose of Cyclophosphamide Combination in Patients With Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer
Brief Summary
This is a phase 2 study whose purpose is to see whether the combination of of pembrolizumab,
DPX-Survivac vaccine and low-dose cyclophosphamide has anti-tumor activity in patients with
advanced epithelial ovarian, fallopian tube or primary peritoneal cancer.
DPX-Survivac is an investigational vaccine. A vaccine is a substance that is often given to
stimulate the body's immune system (the structure and processes in the body that protects
against harmful substances) to help prevent against certain diseases. DPX-Survivac is a
vaccine that may teach the immune system to recognize cancer cells and to kill them.
Pembrolizumab is a drug that is approved for the treatment of a certain type of melanoma (a
type of skin cancer) and non-small cell lung cancer. Pembrolizumab blocks the function of a
protein called programmed cell death receptor-1 (PD-1). PD-1 works by keeping the immune
system from destroying cancer cells. Stopping PD-1 from working may help the immune system to
fight cancer cells.
Cyclophosphamide is chemotherapy drug that is approved for the treatment of various cancers
alone and in combination with other drugs.
Detailed Description
This study has two phases: a dose escalation phase and a dose expansion phase.
For the dose escalation part, groups of participants will receive one of two dose levels of
study drugs to determine the best dose level for further testing.
Once the best dose level is found, additional participant will be enrolled to the dose
expansion to further test the safety, tolerability, and efficacy of the study drugs at that
dose level in specific types of cancers. All participants will receive pembrolizumab,
DPX-Survivac, and low-dose cyclophosphamide.
Participants will be screened for eligibility by standard safety tests and procedures within
28 days of the start of the study drug. Tests and procedures done for research purposes only
during this time include archival tumor tissue collection, fresh research biopsy, and blood
sample collection for biomarker/genetic/immune research. Participants will also be asked if
they agree to an optional fresh research biopsy at disease progression
Eligible participants will receive the following every 21 day cycle:
- Pembrolizumab, intravenously, at 200 mg, on Day 1 of every cycle.
- DPX-Survivac, by injection under the skin of the upper thigh in clinic. Participants
will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6
weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL
DPX-Survivac depending on the assigned dose level.
- Cyclophosphamide, orally, at 50 mg, twice a day, starting about 7 days before Cycle 1
Day 1, then continue 7 days off, 7 days on.
While receiving the study treatment, participants will be asked to visit the study site on
Day 1 of Cycles 1-8 for tests and procedures. Tests and procedures done for research purposes
only include additional blood sample collection and a second fresh research biopsy for
biomarker/genetic/immune research.
Participants who benefit from the study treatment may be able to receive additional treatment
if they progress after stopping the study treatment.
When participants are taken off the study treatment permanently, they will be asked to return
to the study site for an End of Study Treatment visit about 30 days after stopping the study
treatment to have tests and procedures done for safety purposes.
Participants who are taken off the study treatment for any reason other than disease
progression will continue to have radiological assessments and blood draws every 12 weeks for
the first year and every 24 weeks after year 1 until they start a new anti-cancer treatment,
disease progression, or the study ends. Participants will continue to be followed for
survival and to review any new anti-cancer therapies every 12 weeks.
Study Phase
Phase 2
Study Type
Interventional
Primary Outcome
Overall response rate (ORR)
Secondary Outcome
Progression free survival (PFS) rate
Condition
Advanced Cancer
Intervention
Pembrolizumab
Study Arms / Comparison Groups
Dose Escalation
Description: Patients with epithelial ovarian, fallopian tube or primary peritoneal cancer.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
42
Start Date
February 12, 2018
Completion Date
February 12, 2024
Primary Completion Date
February 12, 2023
Eligibility Criteria
Inclusion Criteria:
- Patients must have histologically or cytologically confirmed advanced epithelial
ovarian, primary peritoneal or fallopian tube carcinomas.
- Patients must have radiologically documented disease progression from their prior line
of therapy.
- Patients must have measurable disease based on RECIST 1.1.
- Have received a front line platinum-based regimen (administered via either IV or IP)
following primary or interval debulking surgery with documented disease recurrence.
- Have fulfilled the following additional requirements regarding prior treatments
depending on the cohort that the patient is to be enrolled in.
- Eastern Cooperative Group (ECOG) performance status <=1.
- Life expectancy greater than 16 weeks.
- Availability of archival tumor tissue samples. Additional samples may be requested if
tumor tissue provided is not adequate for quality and/or quantity as assessed by the
laboratory.
- Be willing to provide tumor tissue from a newly obtained core or excisional biopsy
prior to start treatment and on day 15 of cycle 1.
Exclusion Criteria:
- Patients who are receiving any other investigational agents.
- Diagnosis of immunodeficiency or therapy with systemic steroid or any other form of
immunosuppressive therapy within 7 days prior to the first dose of trial treatment.
- History of autoimmune disease, such as but not restricted to, rheumatoid arthritis,
inflammatory bowel disease, systemic lupus erythematous, ankylosing spondylitis,
scleroderma, or multiple sclerosis requiring treatment within the last two years.
Patients with vitiligo or diabetes are not excluded.
- Patients with history of thyroiditis within 5 years.
- Patients with known history of active TB (Bacillus Tuberculosis).
- Patients with known active central nervous system (CNS) metastases and/or
carcinomatous meningitis.
- Hypersensitivity to Pembrolizumab, DPX-Survivac immunovaccine, Cyclophosphamide or any
of their excipients.
- Patients that have received a live vaccine within 30 days of planned start of study
therapy.
- Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2 agent or DPX-Survivac vaccine.
Gender
Female
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Amit Oza, M.D., 416-946-2818, [email protected]
Location Countries
Canada
Location Countries
Canada
Administrative Informations
NCT ID
NCT03029403
Organization ID
PESCO
Responsible Party
Sponsor
Study Sponsor
University Health Network, Toronto
Collaborators
Merck Sharp & Dohme LLC
Study Sponsor
Amit Oza, M.D., Principal Investigator, Princess Margaret Cancer Centre
Verification Date
November 2021