Nutritional Aspects of Rett Syndrome

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Brief Title

Nutritional Aspects of Rett Syndrome


Brief Summary

      OBJECTIVES: I. Determine dietary macronutrient intake in children with Rett syndrome and in
      healthy controls.

      II. Measure sleeping and awake metabolic rates in various positions, i.e., reclining,
      sitting, and standing, by whole-room indirect calorimetry and isotope dilution.

      III. Quantify activity patterns by time-motion studies using 24-hour activity records and
      12-hour videotaping.

      IV. Correlate 24-hour activity patterns with 24-hour heart rate telemetry and short-term
      oxygen consumption.

      V. Estimate 24-hour fecal and urinary energy losses. VI. Determine body composition by
      clinical anthropometry, whole-body potassium counting, and total-body electrical conductance.

      VII. Calculate apparent energy needs based on measurement of energy intake and expenditure.
    

Detailed Description

      PROTOCOL OUTLINE:

      All participants undergo extensive nutritional and metabolic assessment with body composition
      evaluation. Studies include macronutrient intake, body fat, lean muscle mass, metabolic rate,
      and time-action studies; and 24-hour cardiac telemetry. Rett syndrome girls also receive a
      hemogram and hand x-ray.
    


Study Type

Interventional




Condition

Rett Syndrome

Intervention

Metabolic assessment with body composition evaluation


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Procedure


Start Date

May 1993



Eligibility Criteria

        PROTOCOL ENTRY CRITERIA:

        Patients aged 5 to 18 with Rett syndrome Able to sleep and awaken alone
      

Gender

Female

Ages

5 Years - 18 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Kathleen J. Motil, , 



Administrative Informations


NCT ID

NCT00004656

Organization ID

199/11814

Secondary IDs

BCM-CNRC-H1637


Study Sponsor

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborators

 Baylor College of Medicine

Study Sponsor

Kathleen J. Motil, Study Chair, Baylor College of Medicine


Verification Date

February 1999