Advanced Grandparental Age as a Risk Factor for Autism

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Brief Title

Advanced Grandparental Age as a Risk Factor for Autism

Official Title

Advanced Grandparental Age as a Risk Factor for Autism and Other Pervasive Developmental Disorders

Brief Summary

      The Division of Medical Genetics at the University of Mississippi Medical Center is
      recruiting parents of children with a pervasive developmental disorder (including autism,
      autistic spectrum disorder, PDD-NOS, Asperger syndrome, childhood disintegrative disorder,
      and Rett syndrome) to participate in a study to help determine potential causes of the
      increasing prevalence of these disorders. The study is being conducted using an anonymous
      on-line survey available to parents through a secure link.

      The study consists of approximately 90 questions about the affected child, siblings, parents,
      and grandparents, which will take roughly 10-15 minutes to complete. Several families will
      also be invited to participate in a phone interview. Both the survey and the phone interview
      are conducted using a self-designated code to protect anonymity and patient privacy. No
      identifying information such as name, date of birth, address, or phone number will be asked.
      Only questions regarding the year of birth of family members will be asked.
    

Detailed Description

      Autism is a genetically heterogeneous entity. Although numerous studies have demonstrated a
      strong genetic basis, no clear etiology has been identified to date. Recently, two studies
      have demonstrated an increased risk of autism in children born to fathers over the age of 40.
      However, given the large male-to-female predominance of autism, it is likely that new
      mutations on the X chromosome account for a significant number of affected cases. Due to the
      maternal origin of the X chromosome in males, we hypothesize that advanced
      maternal-grandpaternal age may also be a risk factor for autism. Precedence for this theory
      exists with other X-linked disorders such as Duchenne muscular dystrophy and Rett syndrome.
      Additionally, it has been demonstrated that maternal psychiatric illness, but not paternal
      psychiatric illness, is more prevalent among parents of children with autism. Using anonymous
      surveys of families with autistic children, we seek to identify the ages of grandparents at
      the time the parents were born in order to determine if advanced maternal-grandpaternal age
      is associated with an increased risk for autism when adjusted for advanced maternal and
      paternal age. Additionally, we will seek out sister-pairs in order to identify any
      statistical significance between the ages of the maternal grandfather at delivery of each
      sister. If advanced maternal-grandpaternal age is, in fact, a risk factor, it would help
      direct molecular researchers towards genes on the X chromosome as potential etiologies for
      autism. Also, further study of potential mutagenic exposures in the environment of
      grandparents may help elucidate the reason for the increasing incidence of autism in recent
      decades.
    


Study Type

Observational




Condition

Autistic Disorder



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

100

Start Date

June 2007

Completion Date

October 2007


Eligibility Criteria

        Inclusion Criteria:

          -  Individuals of any age with autism, autistic disorder, autistic spectrum disorder,
             Asperger syndrome, pervasive developmental disorder, PDD-NOS, Rett syndrome, or
             Childhood disintegrative disorder
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Omar Abdul-Rahman, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00464477

Organization ID

2007-0023



Study Sponsor

University of Mississippi Medical Center


Study Sponsor

Omar Abdul-Rahman, MD, Principal Investigator, University of Mississippi Medical Center


Verification Date

November 2007