Myocardial Contrast Echocardiography in Congenital Heart Disease

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Brief Title

Myocardial Contrast Echocardiography in Congenital Heart Disease

Official Title

Quantification of the Myocardial Microcirculation by Contrast Echocardiography In Adult Patients With Congenital Heart Disease

Brief Summary

      Patients with congenital heart disease in whom the right ventricle is exposed to pressure or
      volume overload show progressive systolic dysfunction of the right ventricle, the fact of
      which conveys substantial morbidity and mortality. The aim of this study is to investigate
      the myocardial perfusion in these patients by myocardial contrast echocardiography (MCE) in
      order to determine whether disturbed blood flow plays a role in the development of right
      ventricular systolic dysfunction.

Study Type



D-Transposition of Great Arteries

Study Arms / Comparison Groups

 TGA group
Description:  The TGA group consists of 15 patients treated withMustard or Senning procedures for surgical repaired of D-TGA atrial switch operation.


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment


Start Date

August 2006

Completion Date

December 2008

Primary Completion Date

December 2008

Eligibility Criteria

        Inclusion Criteria:

          -  D-TGA or Fallot-Tetralogy or Healthy person

          -  written informed consent

          -  Age >= 18 years

        Exclusion Criteria:

          -  Anaemia

          -  Pregnancy and breast feeding

          -  Diabetes mellitus

          -  Contraindications to stress testing (ergometry or adenosine)

          -  Known adverse reaction or hypersensitivity against V08DA (SonoVue) or its components
             or against adenosine




18 Years - 80 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers


Christian Seiler, Prof., , 

Location Countries


Location Countries


Administrative Informations



Organization ID


Study Sponsor

University Hospital Inselspital, Berne

Study Sponsor

Christian Seiler, Prof., Principal Investigator, University Hospital Berne, Switzerland

Verification Date

June 2015